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Crystal structure of (1S,2R,4S)-1-[(morpholin-4-yl)-methyl]-4-(prop-1-en-2-yl)cyclohexane-1,2-diol
2015, Outouch, Rachid, Oubaassine, Saadia, Ali, Mustapha Ait, El Firdoussi, Larbi, Spannenberg, Anke
The asymmetric unit of the title compound, C14H25NO3, contains two independent molecules with similar geometry. The morpholine and cyclohexane rings of both molecules adopt a chair conformation. Intramolecular O-H...N hydrogen bonds are observed. In the crystal, molecules are linked by O-H...O hydrogen bonds into chains parallel to the [101] direction. The chains are further connected through C-H...O hydrogen bonds forming undulating layers parallel to the (-101) plane. The absolute configuration was assigned by reference to an unchanging chiral centre in the synthetic procedure.
Catalytic β-Bromohydroxylation of Natural Terpenes: Useful Intermediates for the Synthesis of Terpenic Epoxides
2018, Oubaassine, Saadia, Köckritz, Angela, Eckelt, Reinhard, Martin, Andreas, Ait Ali, Mustapha, El Firdoussi, Larbi
In a one-step procedure, various ß-bromoalcohols were synthesized from natural terpenes in good to excellent yields. Using different catalysts, the reaction was carried out at room temperature, with H 2 O as nucleophile and N-bromosuccinimide as a bromine source under mild reaction conditions. The synthesized ß-bromoalcohols were subsequently converted in situ to the corresponding epoxides in good yields. © 2019 Saadia Oubaassine et al.