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Author: Singh, Smriti × End date: 2024 × Start date: 2020 × DDC: 540 × WGL Institute: DWI ×

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    3D-Printing of Structure-Controlled Antigen Nanoparticles for Vaccine Delivery
    (Columbus, Ohio : American Chemical Soc., 2020) Nishiguchi, Akihiro; Shima, Fumiaki; Singh, Smriti; Akashi, Mitsuru; Moeller, Martin
    Targeted delivery of antigens to immune cells using micro/nanocarriers may serve as a therapeutic application for vaccination. However, synthetic carriers have potential drawbacks including cytotoxicity, low encapsulation efficiency of antigen, and lack of a morphological design, which limit the translation of the delivery system to clinical use. Here, we report a carrier-free and three-dimensional (3D)-shape-designed antigen nanoparticle by multiphoton lithography-based 3D-printing. This simple, versatile 3D-printing approach provides freedom for the precise design of particle shapes with a nanoscale resolution. Importantly, shape-designed antigen nanoparticles with distinct aspect ratios show shape-dependent immune responses. The 3D-printing approach for the rational design of nanomaterials with increasing safety, complexity, and efficacy offers an emerging platform to develop vaccine delivery systems and mechanistic understanding.
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    Physical gels of poly(vinylamine) by thermal curing
    (Cambridge : Royal Society of Chemistry, 2020) Fischer, Thorsten; Köhler, Jens; Möller, Martin; Singh, Smriti
    Physical gels are a versatile class of materials which can find application in sensors, electrochemistry, biomedicine or rheological modifiers. Herein, we present a hydrogen-bonded physical gel which is based on the interaction between phenylcarbonate telechelic poly(ethylene glycol) (PEG-PC) and poly(vinyl amine-co-acetamide) (p(VAm-co-VAA)). The critical gelation concentration was found to be 10 wt% by rheology and NMR. UV-vis spectroscopy and dynamic light scattering reveal the formation of aggregates in the gel. Rheology and differential scanning calorimetry (DSC) was used to show the effect of thermal curing on the mechanical properties of the physical gel. © The Royal Society of Chemistry 2020.