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Author: Sprekels, Jürgen × Author: Wu, Hao × Type: Text × Subject: Cahn–Hilliard–Darcy system ×

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    Optimal distributed control of a Cahn-Hilliard-Darcy system with mass sources
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2018) Sprekels, Jürgen; Wu, Hao
    In this paper, we study an optimal control problem for a two-dimensional CahnHilliardDarcy system with mass sources that arises in the modeling of tumor growth. The aim is to monitor the tumor fraction in a finite time interval in such a way that both the tumor fraction, measured in terms of a tracking type cost functional, is kept under control and minimal harm is inflicted to the patient by administering the control, which could either be a drug or nutrition. We first prove that the optimal control problem admits a solution. Then we show that the control-to-state operator is Fréchet differentiable between suitable Banach spaces and derive the first-order necessary optimality conditions in terms of the adjoint variables and the usual variational inequality.