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Author: Sprekels, Jürgen × End date: 2022 × Start date: 2022 × Type: Text × Type: report × Publisher: Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik × Subject: necessary optimality conditions ×

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    Well-posedness and optimal control for a Cahn--Hilliard--Oono system with control in the mass term
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2021) Colli, Pierluigi; Gilardi, Gianni; Rocca, Elisabetta; Sprekels, Jürgen
    The paper treats the problem of optimal distributed control of a Cahn--Hilliard--Oono system in Rd, 1 ≤ d ≤ 3 with the control located in the mass term and admitting general potentials that include both the case of a regular potential and the case of some singular potential. The first part of the paper is concerned with the dependence of the phase variable on the control variable. For this purpose, suitable regularity and continuous dependence results are shown. In particular, in the case of a logarithmic potential, we need to prove an ad hoc strict separation property, and for this reason we have to restrict ourselves to the case d = 2. In the rest of the work, we study the necessary first-order optimality conditions, which are proved under suitable compatibility conditions on the initial datum of the phase variable and the time derivative of the control, at least in case of potentials having unbounded domain
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    A distributed control problem for a fractional tumor growth model
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2019) Colli, Pierluigi; Gilardi, Gianni; Sprekels, Jürgen
    In this paper, we study the distributed optimal control of a system of three evolutionary equations involving fractional powers of three selfadjoint, monotone, unbounded linear operators having compact resolvents. The system is a generalization of a Cahn--Hilliard type phase field system modeling tumor growth that goes back to Hawkins-Daarud et al. (Int. J. Numer. Math. Biomed. Eng. 28 (2012), 3--24.) The aim of the control process, which could be realized by either administering a drug or monitoring the nutrition, is to keep the tumor cell fraction under control while avoiding possible harm for the patient. In contrast to previous studies, in which the occurring unbounded operators governing the diffusional regimes were all given by the Laplacian with zero Neumann boundary conditions, the operators may in our case be different; more generally, we consider systems with fractional powers of the type that were studied in the recent work Adv. Math. Sci. Appl. 28 (2019), 343--375 by the present authors. In our analysis, we show the Fréchet differentiability of the associated control-to-state operator, establish the existence of solutions to the associated adjoint system, and derive the first-order necessary conditions of optimality for a cost functional of tracking type.
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    Optimal control of a phase field system modelling tumor growth with chemotaxis and singular potentials
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2019) Colli, Pierluigi; Signori, Andrea; Sprekels, Jürgen
    A distributed optimal control problem for an extended model of phase field type for tumor growth is addressed. In this model, the chemotaxis effects are also taken into account. The control is realized by two control variables that design the dispensation of some drugs to the patient. The cost functional is of tracking type, whereas the potential setting has been kept quite general in order to allow regular and singular potentials to be considered. In this direction, some relaxation terms have been introduced in the system. We show the well-posedness of the state system, the Fréchet differentiability of the control-to-state operator in a suitable functional analytic framework, and, lastly, we characterize the first-order necessary conditions of optimality in terms of a variational inequality involving the adjoint variables.