21 results
Search Results
Now showing 1 - 10 of 21
- ItemLongtime behavior for a generalized Cahn-Hilliard system with fractional operators(Messina : Accademia Peloritana dei Pericolanti, 2020) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenIn this contribution, we deal with the longtime behavior of the solutions to the fractional variant of the Cahn-Hilliard system, with possibly singular potentials, that we have recently investigated in the paper Well-posedness and regularity for a generalized fractional Cahn-Hilliard system. More precisely, we study the ω-limit of the phase parameter y and characterize it completely. Our characterization depends on the first eigenvalues λ1≥0 of one of the operators involved: if λ1>0, then the chemical potential μ vanishes at infinity and every element yω of the ω-limit is a stationary solution to the phase equation; if instead λ1=0, then every element yω of the ω-limit satisfies a problem containing a real function μ∞ related to the chemical potential μ. Such a function μ∞ is nonunique and time dependent, in general, as we show by an example. However, we give sufficient conditions for μ∞ to be uniquely determined and constant.
- ItemA boundary control problem for the pure Cahn–Hilliard equation with dynamic boundary conditions(Berlin ; Boston, Mass. : de Gruyter, 2015) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenA boundary control problem for the pure Cahn–Hilliard equations with possibly singular potentialsand dynamic boundary conditions is studied and rst-order necessary conditions for optimality are proved.
- ItemDistributed optimal control of a nonstandard nonlocal phase field system(Springfield, MO : AIMS Press, 2016) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenWe investigate a distributed optimal control problem for a nonlocal phase field model of viscous Cahn-Hilliard type. The model constitutes a nonlocal version of a model for two-species phase segregation on an atomic lattice under the presence of diffusion that has been studied in a series of papers by P. Podio-Guidugli and the present authors. The model consists of a highly nonlinear parabolic equation coupled to an ordinary differential equation. The latter equation contains both nonlocal and singular terms that render the analysis difficult. Standard arguments of optimal control theory do not apply directly, although the control constraints and the cost functional are of standard type. We show that the problem admits a solution, and we derive the first-order necessary conditions of optimality.
- ItemOptimal Control Problems with Sparsity for Tumor Growth Models Involving Variational Inequalities(Dordrecht [u.a.] : Springer Science + Business Media, 2022) Colli, Pierluigi; Signori, Andrea; Sprekels, JürgenThis paper treats a distributed optimal control problem for a tumor growth model of Cahn–Hilliard type. The evolution of the tumor fraction is governed by a variational inequality corresponding to a double obstacle nonlinearity occurring in the associated potential. In addition, the control and state variables are nonlinearly coupled and, furthermore, the cost functional contains a nondifferentiable term like the L1-norm in order to include sparsity effects which is of utmost relevance, especially time sparsity, in the context of cancer therapies as applying a control to the system reflects in exposing the patient to an intensive medical treatment. To cope with the difficulties originating from the variational inequality in the state system, we employ the so-called deep quench approximation in which the convex part of the double obstacle potential is approximated by logarithmic functions. For such functions, first-order necessary conditions of optimality can be established by invoking recent results. We use these results to derive corresponding optimality conditions also for the double obstacle case, by deducing a variational inequality in terms of the associated adjoint state variables. The resulting variational inequality can be exploited to also obtain sparsity results for the optimal controls.
- ItemAn asymptotic analysis for a generalized Cahn–Hilliard system with fractional operators(Basel : Springer, 2021) Colli, Pierluigi; Gilardi, Gianni; Sprekels, JürgenIn the recent paper “Well-posedness and regularity for a generalized fractional Cahn–Hilliard system” (Colli et al. in Atti Accad Naz Lincei Rend Lincei Mat Appl 30:437–478, 2019), the same authors have studied viscous and nonviscous Cahn–Hilliard systems of two operator equations in which nonlinearities of double-well type, like regular or logarithmic potentials, as well as nonsmooth potentials with indicator functions, were admitted. The operators appearing in the system equations are fractional powers A2r and B2σ (in the spectral sense) of general linear operators A and B, which are densely defined, unbounded, selfadjoint, and monotone in the Hilbert space L2(Ω), for some bounded and smooth domain Ω⊂R3, and have compact resolvents. Existence, uniqueness, and regularity results have been proved in the quoted paper. Here, in the case of the viscous system, we analyze the asymptotic behavior of the solution as the parameter σ appearing in the operator B2σ decreasingly tends to zero. We prove convergence to a phase relaxation problem at the limit, and we also investigate this limiting problem, in which an additional term containing the projection of the phase variable on the kernel of B appears.
- ItemSecond-order analysis of an optimal control problem in a phase field tumor growth model with singular potentials and chemotaxis(Les Ulis : EDP Sciences, 2021) Colli, Pierluigi; Signori, Andrea; Sprekels, JürgenThis paper concerns a distributed optimal control problem for a tumor growth model of Cahn–Hilliard type including chemotaxis with possibly singular potentials, where the control and state variables are nonlinearly coupled. First, we discuss the weak well-posedness of the system under very general assumptions for the potentials, which may be singular and nonsmooth. Then, we establish the strong well-posedness of the system in a reduced setting, which however admits the logarithmic potential: this analysis will lay the foundation for the study of the corresponding optimal control problem. Concerning the optimization problem, we address the existence of minimizers and establish both first-order necessary and second-order sufficient conditions for optimality. The mathematically challenging second-order analysis is completely performed here, after showing that the solution mapping is twice continuously differentiable between suitable Banach spaces via the implicit function theorem. Then, we completely identify the second-order Fréchet derivative of the control-to-state operator and carry out a thorough and detailed investigation about the related properties.
- ItemOptimal control of a phase field system modelling tumor growth with chemotaxis and singular potentials(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2019) Colli, Pierluigi; Signori, Andrea; Sprekels, JürgenA distributed optimal control problem for an extended model of phase field type for tumor growth is addressed. In this model, the chemotaxis effects are also taken into account. The control is realized by two control variables that design the dispensation of some drugs to the patient. The cost functional is of tracking type, whereas the potential setting has been kept quite general in order to allow regular and singular potentials to be considered. In this direction, some relaxation terms have been introduced in the system. We show the well-posedness of the state system, the Fréchet differentiability of the control-to-state operator in a suitable functional analytic framework, and, lastly, we characterize the first-order necessary conditions of optimality in terms of a variational inequality involving the adjoint variables.
- ItemAnalysis of a tumor model as a multicomponent deformable porous medium(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2021) Krejčí, Pavel; Rocca, Elisabetta; Sprekels, JürgenWe propose a diffuse interface model to describe tumor as a multicomponent deformable porous medium. We include mechanical effects in the model by coupling the mass balance equations for the tumor species and the nutrient dynamics to a mechanical equilibrium equation with phase-dependent elasticity coefficients. The resulting PDE system couples two Cahn--Hilliard type equations for the tumor phase and the healthy phase with a PDE linking the evolution of the interstitial fluid to the pressure of the system, a reaction-diffusion type equation for the nutrient proportion, and a quasistatic momentum balance. We prove here that the corresponding initial-boundary value problem has a solution in appropriate function spaces.
- ItemSecond-order analysis of an optimal control problem in a phase field tumor growth model with singular potentials and chemotaxis(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2020) Colli, Pierluigi; Signori, Andrea; Sprekels, JürgenThis paper concerns a distributed optimal control problem for a tumor growth model of Cahn--Hilliard type including chemotaxis with possibly singular anpotentials, where the control and state variables are nonlinearly coupled. First, we discuss the weak well-posedness of the system under very general assumptions for the potentials, which may be singular and nonsmooth. Then, we establish the strong well-posedness of the system in a reduced setting, which however admits the logarithmic potential: this analysis will lay the foundation for the study of the corresponding optimal control problem. Concerning the optimization problem, we address the existence of minimizers and establish both first-order necessary and second-order sufficient conditions for optimality. The mathematically challenging second-order analysis is completely performed here, after showing that the solution mapping is twice continuously differentiable between suitable Banach spaces via the implicit function theorem. Then, we completely identify the second-order Fréchet derivative of the control-to-state operator and carry out a thorough and detailed investigation about the related properties.
- ItemAnalysis and optimal control theory for a phase field model of Caginalp type with thermal memory(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2021) Colli, Pierluigi; Signori, Andrea; Sprekels, JürgenA nonlinear extension of the Caginalp phase field system is considered that takes thermal memory into account. The resulting model, which is a first-order approximation of a thermodynamically consistent system, is inspired by the theories developed by Green and Naghdi. Two equations, resulting from phase dynamics and the universal balance law for internal energy, are written in terms of the phase variable (representing a non-conserved order parameter) and the so-called thermal displacement, i.e., a primitive with respect to time of temperature. Existence and continuous dependence results are shown for weak and strong solutions to the corresponding initial-boundary value problem. Then, an optimal control problem is investigated for a suitable cost functional, in which two data act as controls, namely, the distributed heat source and the initial temperature. Fréchet differentiability between suitable Banach spaces is shown for the control-to-state operator, and meaningful first-order necessary optimality conditions are derived in terms of variational inequalities involving the adjoint variables. Eventually, characterizations of the optimal controls are given.
- «
- 1 (current)
- 2
- 3
- »