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    Well-posedness for a class of phase-field systems modeling prostate cancer growth with fractional operators and general nonlinearities
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2021) Colli, Pierluigi; Gilardi, Gianni; Sprekels, Jürgen
    This paper deals with a general system of equations and conditions arising from a mathematical model of prostate cancer growth with chemotherapy and antiangiogenic therapy that has been recently introduced and analyzed (see [P. Colli et al., Mathematical analysis and simulation study of a phase-field model of prostate cancer growth with chemotherapy and antiangiogenic therapy effects, Math. Models Methods Appl. Sci. bf 30 (2020), 1253--1295]). The related system includes two evolutionary operator equations involving fractional powers of selfadjoint, nonnegative, unbounded linear operators having compact resolvents. Both equations contain nonlinearities and in particular the equation describing the dynamics of the tumor phase variable has the structure of a Allen--Cahn equation with double-well potential and additional nonlinearity depending also on the other variable, which represents the nutrient concentration. The equation for the nutrient concentration is nonlinear as well, with a term coupling both variables. For this system we design an existence, uniqueness and continuous dependence theory by setting up a careful analysis which allows the consideration of nonsmooth potentials and the treatment of continuous nonlinearities with general growth properties.
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    Continuous dependence for a nonstandard Cahn-Hilliard system with nonlinear atom mobility
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2012) Colli, Pierluigi; Gilardi, Gianni; Podio-Guidugli, Paolo; Sprekels, Jürgen
    This note is concerned with a nonlinear diffusion problem of phase-field type, consisting of a parabolic system of two partial differential equations, complemented by Neumann homogeneous boundary conditions and initial conditions. The system arises from a model of two-species phase segregation on an atomic lattice [Podio-Guidugli 2006]; it consists of the balance equations of microforces and microenergy; the two unknowns are the order parameter $rho$ and the chemical potential $mu$. Some recent results obtained for this class of problems is reviewed and, in the case of a nonconstant and nonlinear atom mobility, uniqueness and continuous dependence on the initial data are shown with the help of a new line of argumentation developed in Colli/Gilardi/Podio-Guidugli/Sprekels 2012.
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    Global existence and uniqueness for a singular/degenerate Cahn-Hilliard system with viscosity
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2012) Colli, Pierluigi; Gilardi, Gianni; Podio-Guidugli, Paolo; Sprekels, Jürgen
    Existence and uniqueness are investigated for a nonlinear diffusion problem of phase-field type, consisting of a parabolic system of two partial differential equations, complemented by Neumann homogeneous boundary conditions and initial conditions. This system aims to model two-species phase segregation on an atomic [19]; in the balance equations of microforces and microenergy, the two unknowns are the order parameter $rho$ and the chemical potential $mu$. A simpler version of the same system has recently been discussed in [8]. In this paper, a fairly more general phase-field equation for $rho$ is coupled with a genuinely nonlinear diffusion equation for $mu$. The existence of a global-in-time solution is proved with the help of suitable a priori estimates. In the case of costant atom mobility, a new and rather unusual uniqueness proof is given, based on a suitable combination of variables.