2017, Kinzel, Julia, Sauer, Daniel F., Bocola, Marco, Arlt, Marcus, Mirzaei Garakani, Tayebeh, Thiel, Andreas, Beckerle, Klaus, Polen, Tino, Okuda, Jun, Schwaneberg, Ulrich

Covering hydrophobic regions with stabilization agents to solubilize purified transmembrane proteins is crucial for their application in aqueous media. The small molecule 2-methyl-2,4-pentanediol (MPD) was used to stabilize the transmembrane protein Ferric hydroxamate uptake protein component A (FhuA) utilized as host for the construction of a rhodium-based biohybrid catalyst. Unlike commonly used detergents such as sodium dodecyl sulfate or polyethylene polyethyleneglycol, MPD does not form micelles in solution. Molecular dynamics simulations revealed the effect and position of stabilizing MPD molecules. The advantage of the amphiphilic MPD over micelle-forming detergents is demonstrated in the polymerization of phenylacetylene, showing a ten-fold increase in yield and increased molecular weights.

2020, Adamseged, Muluken E., Frija, Aymen, Thiel, Andreas

The authors regret for not properly acknowledging the contribution of the Consortium Research Program (CRP) on Livestock, led by ILRI with contribution of ICARDA. Funding from the CGIAR Research Program on Livestock (flagship 5 on “Livestock livelihoods and agri-food systems flagship”) is acknowledged for their support of staff time of Dr. Aymen Frija. The authors thank all donors and organizations who globally support the work of the CGIAR Research Program on Livestock through their contributions to the CGIAR system. The authors would like to apologise for any inconvenience caused. © 2020 The Author(s)

2019, Adamseged, Muluken E., Frija, Aymen, Thiel, Andreas

[No abstract available]