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Author: Vidal, Maria-Esther × End date: 2019 × Type: BookPart × Version: publishedVersion × WGL Institute: TIB ×

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    Interaction Network Analysis Using Semantic Similarity Based on Translation Embeddings
    (Berlin ; Heidelberg : Springer, 2019) Manzoor Bajwa, Awais; Collarana, Diego; Vidal, Maria-Esther; Acosta, Maribel; Cudré-Mauroux, Philippe; Maleshkova, Maria; Pellegrini, Tassilo; Sack, Harald; Sure-Vetter, York
    Biomedical knowledge graphs such as STITCH, SIDER, and Drugbank provide the basis for the discovery of associations between biomedical entities, e.g., interactions between drugs and targets. Link prediction is a paramount task and represents a building block for supporting knowledge discovery. Although several approaches have been proposed for effectively predicting links, the role of semantics has not been studied in depth. In this work, we tackle the problem of discovering interactions between drugs and targets, and propose SimTransE, a machine learning-based approach that solves this problem effectively. SimTransE relies on translating embeddings to model drug-target interactions and values of similarity across them. Grounded on the vectorial representation of drug-target interactions, SimTransE is able to discover novel drug-target interactions. We empirically study SimTransE using state-of-the-art benchmarks and approaches. Experimental results suggest that SimTransE is competitive with the state of the art, representing, thus, an effective alternative for knowledge discovery in the biomedical domain.
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    Preface
    (Aachen, Germany : RWTH Aachen, 2019) Kaffee, Lucie-Aimee; Endris, Kemele M.; Vidal, Maria-Esther; Comerio, Marco; Sadeghi, Mersedeh; Chaves-Fraga; David, Colpaert Pieter; Kaffee, Lucie Aimée; Endris, Kemele M.; Vidal, María-Esther; Comerio, Marco; Sadeghi, Mersedeh; Chaves-Fraga, David; Colpaert, Pieter
    This volumne presents the proceedings of the 1st International Workshop on Approaches for Making Data Interoperable (AMAR 2019) and 1st International Workshop on Semantics for Transport (Sem4Tra) held in Karlsruhe, Germany, September 9, 2019, co-located with SEMANTiCS 2019. Interoperability of data is an important factor to make transportation data accessible, therefore we present the topics alongside each other in this proceedings.
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    Formalizing Gremlin pattern matching traversals in an integrated graph Algebra
    (Aachen, Germany : RWTH Aachen, 2019) Thakkar, Harsh; Auer, Sören; Vidal, Maria-Esther; Samavi, Reza; Consens, Mariano P.; Khatchadourian, Shahan; Nguyen, Vinh; Sheth, Amit; Giménez-García, José M.; Thakkar, Harsh
    Graph data management (also called NoSQL) has revealed beneficial characteristics in terms of flexibility and scalability by differ-ently balancing between query expressivity and schema flexibility. This peculiar advantage has resulted into an unforeseen race of developing new task-specific graph systems, query languages and data models, such as property graphs, key-value, wide column, resource description framework (RDF), etc. Present-day graph query languages are focused towards flex-ible graph pattern matching (aka sub-graph matching), whereas graph computing frameworks aim towards providing fast parallel (distributed) execution of instructions. The consequence of this rapid growth in the variety of graph-based data management systems has resulted in a lack of standardization. Gremlin, a graph traversal language, and machine provide a common platform for supporting any graph computing sys-tem (such as an OLTP graph database or OLAP graph processors). In this extended report, we present a formalization of graph pattern match-ing for Gremlin queries. We also study, discuss and consolidate various existing graph algebra operators into an integrated graph algebra.