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- ItemMultilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion([London] : Macmillan Publishers Limited, part of Springer Nature, 2019) Chae, Soo Sang; Jung, Joo Hyun; Choi, Won Jin; Park, Joung Kyu; Baik, Hong Koo; Jung, Jongjin; Ko, Hyuk WanPrecise modulation of polymer brush in its thickness and grafting density can cause unexpected cell behaviors and regulated bioactivities. Herein, a nanoscale poly(dimethylsiloxane) (PDMS) brush was employed to use as a controllable material for cell adhesion. Facile fabrication of ultrathin monolayer PDMS nanobrush on an underlying substrate facilitated regaining cell adhesion through long-range cell attractive forces such as the van der Waals forces. We showed that cell adhesion is diminished by increasing the number of nanobrush layers, causing a gradual decrease of the effectiveness of the long-range force. The result demonstrates that ultrathin PDMS nanobrush can either promote or inhibit cell adhesion, which is required for various biomedical fields such as tissue-engineering, anti-fouling coating, and implantable biomaterials and sensors.