Search Results
Photobiomodulation of lymphatic drainage and clearance: Perspective strategy for augmentation of meningeal lymphatic functions
2020, Semyachkina-Glushkovskaya, Oxana, Abdurashitov, Arkady, Dubrovsky, Alexander, Klimova, Maria, Agranovich, Ilana, Terskov, Andrey, Shirokov, Alexander, Vinnik, Valeria, Kuzmina, Anna, Lezhnev, Nikita, Blokhina, Inna, Shnitenkova, Anastassia, Tuchin, Valery, Rafailov, Edik, Kurths, Jurgen
There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance. Our results obtained at optical coherence tomography (OCT) give strong evidence that low PBM doses (5 and 10 J/cm2) stimulate drainage function of the lymphatic vessels via vasodilation (OCT data on the mesenteric lymphatics) and stimulation of lymphatic clearance (OCT data on clearance of gold nanorods from the brain) that was supported by confocal imaging of clearance of FITC-dextran from the cortex via MLVs. We assume that PBM-mediated relaxation of the lymphatic vessels can be possible mechanisms underlying increasing the permeability of the lymphatic endothelium that allows molecules transported by the lymphatic vessels and explain PBM stimulation of lymphatic drainage and clearance. These findings open new strategies for the stimulation of MLVs functions and non-pharmacological therapy of brain diseases.
Open-access platform to synthesize knowledge of ape conservation across sites
2020-11-10, Heinicke, Stefanie, Ordaz‐Németh, Isabel, Junker, Jessica, Bachmann, Mona E., Marrocoli, Sergio, Wessling, Erin G., Byler, Dirck, Cheyne, Susan M., Desmond, Jenny, Dowd, Dervla, Fitzgerald, Maegan, Fourrier, Marc, Goedmakers, Annemarie, Hernandez‐Aguilar, R. Adriana, Hillers, Annika, Hockings, Kimberley J., Jones, Sorrel, Kaiser, Michael, Koops, Kathelijne, Lapuente, Juan M., Maisels, Fiona, Riedel, Julia, Terrade, Emilien, Tweh, Clement G., Vergnes, Virginie, Vogt, Tina, Williamson, Elizabeth A., Kühl, Hjalmar S.
Despite the large body of literature on ape conservation, much of the data needed for evidence-based conservation decision-making is still not readily accessible and standardized, rendering cross-site comparison difficult. To support knowledge synthesis and to complement the IUCN SSC Ape Populations, Environments and Surveys database, we created the A.P.E.S. Wiki (https://apeswiki.eva.mpg.de), an open-access platform providing site-level information on ape conservation status and context. The aim of this Wiki is to provide information and data about geographical ape locations, to curate information on individuals and organizations active in ape research and conservation, and to act as a tool to support collaboration between conservation practitioners, scientists, and other stakeholders. To illustrate the process and benefits of knowledge synthesis, we used the momentum of the update of the conservation action plan for western chimpanzees (Pan troglodytes verus) and began with this critically endangered taxon. First, we gathered information on 59 sites in West Africa from scientific publications, reports, and online sources. Information was compiled in a standardized format and can thus be summarized using a web scraping approach. We then asked experts working at those sites to review and complement the information (20 sites have been reviewed to date). We demonstrate the utility of the information available through the Wiki, for example, for studying species distribution. Importantly, as an open-access platform and based on the well-known wiki layout, the A.P.E.S. Wiki can contribute to direct and interactive information sharing and promote the efforts invested by the ape research and conservation community. The Section on Great Apes and the Section on Small Apes of the IUCN SSC Primate Specialist Group will guide and support the expansion of the platform to all small and great ape taxa. Similar collaborative efforts can contribute to extending knowledge synthesis to all nonhuman primate species.
Information exchange in laboratory markets: competition, transfer costs, and the emergence of reputation
2020, Hoffmann, Roman, Kittel, Bernhard, Larsen, Mattias
Public reputation mechanisms are an effective means to limit opportunistic behavior in markets suffering from moral hazard problems. While previous research was mostly concerned with the influence of exogenous feedback mechanisms, this study considers the endogenous emergence of reputation through deliberate information sharing among actors and the role of barriers in hindering information exchange. Using a repeated investment game, we analyze the effects of competition and transfer costs on players’ willingness to share information with each other. While transfer costs are a direct cost of the information exchange, competition costs represent an indirect cost that arises when the transfer of valuable information to competitors comes at the loss of a competitive advantage. We show that barriers to information exchange not only affect the behavior of the senders of information, but also affect the ones about whom the information is shared. While the possibility of sharing information about others significantly improves trust and market efficiency, both competition and direct transfer costs diminish the positive effect by substantially reducing the level of information exchange. Players about whom the information is shared anticipate and react to the changes in the costs by behaving more or less cooperatively. For reputation building, an environment is needed that fosters the sharing of information. Reciprocity is key to understanding information exchange. Even when it is costly, information sharing is used as a way to sanction others. © 2020, The Author(s).
The shared socio-economic pathway (SSP) greenhouse gas concentrations and their extensions to 2500
2020, Meinshausen, Malte, Nicholls, Zebedee R. J., Lewis, Jared, Gidden, Matthew J., Vogel, Elisabeth, Freund, Mandy, Beyerle, Urs, Gessner, Claudia, Nauels, Alexander, Bauer, Nico, Canadell, Josep G., Daniel, John S., John, Andrew, Krummel, Paul B., Luderer, Gunnar, Meinshausen, Nicolai, Montzka, Stephen A., Rayner, Peter J., Reimann, Stefan, Smith, Steven J., van den Berg, Marten, Velders, Guus J. M., Vollmer, Martin K., Wang, Ray H. J.
Anthropogenic increases in atmospheric greenhouse gas concentrations are the main driver of current and future climate change. The integrated assessment community has quantified anthropogenic emissions for the shared socio-economic pathway (SSP) scenarios, each of which represents a different future socio-economic projection and political environment. Here, we provide the greenhouse gas concentrations for these SSP scenarios – using the reduced-complexity climate–carbon-cycle model MAGICC7.0. We extend historical, observationally based concentration data with SSP concentration projections from 2015 to 2500 for 43 greenhouse gases with monthly and latitudinal resolution. CO2 concentrations by 2100 range from 393 to 1135 ppm for the lowest (SSP1-1.9) and highest (SSP5-8.5) emission scenarios, respectively. We also provide the concentration extensions beyond 2100 based on assumptions regarding the trajectories of fossil fuels and land use change emissions, net negative emissions, and the fraction of non-CO2 emissions. By 2150, CO2 concentrations in the lowest emission scenario are approximately 350 ppm and approximately plateau at that level until 2500, whereas the highest fossil-fuel-driven scenario projects CO2 concentrations of 1737 ppm and reaches concentrations beyond 2000 ppm by 2250. We estimate that the share of CO2 in the total radiative forcing contribution of all considered 43 long-lived greenhouse gases increases from 66 % for the present day to roughly 68 % to 85 % by the time of maximum forcing in the 21st century. For this estimation, we updated simple radiative forcing parameterizations that reflect the Oslo Line-By-Line model results. In comparison to the representative concentration pathways (RCPs), the five main SSPs (SSP1-1.9, SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5) are more evenly spaced and extend to lower 2100 radiative forcing and temperatures. Performing two pairs of six-member historical ensembles with CESM1.2.2, we estimate the effect on surface air temperatures of applying latitudinally and seasonally resolved GHG concentrations. We find that the ensemble differences in the March–April–May (MAM) season provide a regional warming in higher northern latitudes of up to 0.4 K over the historical period, latitudinally averaged of about 0.1 K, which we estimate to be comparable to the upper bound (∼5 % level) of natural variability. In comparison to the comparatively straight line of the last 2000 years, the greenhouse gas concentrations since the onset of the industrial period and this studies' projections over the next 100 to 500 years unequivocally depict a “hockey-stick” upwards shape. The SSP concentration time series derived in this study provide a harmonized set of input assumptions for long-term climate science analysis; they also provide an indication of the wide set of futures that societal developments and policy implementations can lead to – ranging from multiple degrees of future warming on the one side to approximately 1.5 ∘C warming on the other.
Near Real-Time Biophysical Rice (Oryza sativa L.) Yield Estimation to Support Crop Insurance Implementation in India
2020, Arumugam, Ponraj, Chemura, Abel, Schauberger, Bernhard, Gornott, Christoph
Immediate yield loss information is required to trigger crop insurance payouts, which are important to secure agricultural income stability for millions of smallholder farmers. Techniques for monitoring crop growth in real-time and at 5 km spatial resolution may also aid in designing price interventions or storage strategies for domestic production. In India, the current government-backed PMFBY (Pradhan Mantri Fasal Bima Yojana) insurance scheme is seeking such technologies to enable cost-efficient insurance premiums for Indian farmers. In this study, we used the Decision Support System for Agrotechnology Transfer (DSSAT) to estimate yield and yield anomalies at 5 km spatial resolution for Kharif rice (Oryza sativa L.) over India between 2001 and 2017. We calibrated the model using publicly available data: namely, gridded weather data, nutrient applications, sowing dates, crop mask, irrigation information, and genetic coefficients of staple varieties. The model performance over the model calibration years (2001–2015) was exceptionally good, with 13 of 15 years achieving more than 0.7 correlation coefficient (r), and more than half of the years with above 0.75 correlation with observed yields. Around 52% (67%) of the districts obtained a relative Root Mean Square Error (rRMSE) of less than 20% (25%) after calibration in the major rice-growing districts (>25% area under cultivation). An out-of-sample validation of the calibrated model in Kharif seasons 2016 and 2017 resulted in differences between state-wise observed and simulated yield anomalies from –16% to 20%. Overall, the good ability of the model in the simulations of rice yield indicates that the model is applicable in selected states of India, and its outputs are useful as a yield loss assessment index for the crop insurance scheme PMFBY.
Prominent role of volcanism in Common Era climate variability and human history
2020, Büntgen, Ulf, Arseneault, Dominique, Boucher, Étienne, Churakova, Olga V., Gennaretti, Fabio, Crivellaro, Alan, Hughes, Malcolm K., Kirdyanov, Alexander V., Klippel, Lara, Krusic, Paul J., Linderholm, Hans W., Ljungqvist, Fredrik C., Ludescher, Josef, McCormick, Michael, Myglan, Vladimir S., Nicolussi, Kurt, Piermattei, Alma, Oppenheimer, Clive, Reinig, Frederick, Sigl, Michael, Vaganov, Eugene A., Esper, Jan
Climate reconstructions for the Common Era are compromised by the paucity of annually-resolved and absolutely-dated proxy records prior to medieval times. Where reconstructions are based on combinations of different climate archive types (of varying spatiotemporal resolution, dating uncertainty, record length and predictive skill), it is challenging to estimate past amplitude ranges, disentangle the relative roles of natural and anthropogenic forcing, or probe deeper interrelationships between climate variability and human history. Here, we compile and analyse updated versions of all the existing summer temperature sensitive tree-ring width chronologies from the Northern Hemisphere that span the entire Common Era. We apply a novel ensemble approach to reconstruct extra-tropical summer temperatures from 1 to 2010 CE, and calculate uncertainties at continental to hemispheric scales. Peak warming in the 280s, 990s and 1020s, when volcanic forcing was low, was comparable to modern conditions until 2010 CE. The lowest June–August temperature anomaly in 536 not only marks the beginning of the coldest decade, but also defines the onset of the Late Antique Little Ice Age (LALIA). While prolonged warmth during Roman and medieval times roughly coincides with the tendency towards societal prosperity across much of the North Atlantic/European sector and East Asia, major episodes of volcanically-forced summer cooling often presaged widespread famines, plague outbreaks and political upheavals. Our study reveals a larger amplitude of spatially synchronized summer temperature variation during the first millennium of the Common Era than previously recognised.
The GGCMI Phase 2 experiment: Global gridded crop model simulations under uniform changes in CO2, temperature, water, and nitrogen levels (protocol version 1.0)
2020, Franke, James A., Müller, Christoph, Elliott, Joshua, Ruane, Alex C., Jägermeyr, Jonas, Balkovic, Juraj, Ciais, Philippe, Dury, Marie, Falloon, Pete D., Folberth, Christian, François, Louis, Hank, Tobias, Hoffmann, Munir, Izaurralde, R. Cesar, Jacquemin, Ingrid, Jones, Curtis, Khabarov, Nikolay, Koch, Marian, Li, Michelle, Liu, Wenfeng, Olin, Stefan, Phillips, Meridel, Pugh, Thomas A. M., Reddy, Ashwan, Wang, Xuhui, Williams, Karina, Zabel, Florian, Moyer, Elisabeth J.
Concerns about food security under climate change motivate efforts to better understand future changes in crop yields. Process-based crop models, which represent plant physiological and soil processes, are necessary tools for this purpose since they allow representing future climate and management conditions not sampled in the historical record and new locations to which cultivation may shift. However, process-based crop models differ in many critical details, and their responses to different interacting factors remain only poorly understood. The Global Gridded Crop Model Intercomparison (GGCMI) Phase 2 experiment, an activity of the Agricultural Model Intercomparison and Improvement Project (AgMIP), is designed to provide a systematic parameter sweep focused on climate change factors and their interaction with overall soil fertility, to allow both evaluating model behavior and emulating model responses in impact assessment tools. In this paper we describe the GGCMI Phase 2 experimental protocol and its simulation data archive. A total of 12 crop models simulate five crops with systematic uniform perturbations of historical climate, varying CO2, temperature, water supply, and applied nitrogen (“CTWN”) for rainfed and irrigated agriculture, and a second set of simulations represents a type of adaptation by allowing the adjustment of growing season length. We present some crop yield results to illustrate general characteristics of the simulations and potential uses of the GGCMI Phase 2 archive. For example, in cases without adaptation, modeled yields show robust decreases to warmer temperatures in almost all regions, with a nonlinear dependence that means yields in warmer baseline locations have greater temperature sensitivity. Inter-model uncertainty is qualitatively similar across all the four input dimensions but is largest in high-latitude regions where crops may be grown in the future.
Incorporating Biodiversity into Biogeochemistry Models to Improve Prediction of Ecosystem Services in Temperate Grasslands: Review and Roadmap
2020, Van Oijen, Marcel, Barcza, Zoltán, Confalonieri, Roberto, Korhonen, Panu, Kröel-Dulay, György, Lellei-Kovács, Eszter, Louarn, Gaëtan, Louault, Frédérique, Martin, Raphaël, Moulin, Thibault, Movedi, Ermes, Picon-Cochard, Catherine, Rolinski, Susanne, Viovy, Nicolas, Wirth, Stephen Björn, Bellocchi, Gianni
Multi-species grasslands are reservoirs of biodiversity and provide multiple ecosystem services, including fodder production and carbon sequestration. The provision of these services depends on the control exerted on the biogeochemistry and plant diversity of the system by the interplay of biotic and abiotic factors, e.g., grazing or mowing intensity. Biogeochemical models incorporate a mechanistic view of the functioning of grasslands and provide a sound basis for studying the underlying processes. However, in these models, the simulation of biogeochemical cycles is generally not coupled to simulation of plant species dynamics, which leads to considerable uncertainty about the quality of predictions. Ecological models, on the other hand, do account for biodiversity with approaches adopted from plant demography, but without linking the dynamics of plant species to the biogeochemical processes occurring at the community level, and this hampers the models’ capacity to assess resilience against abiotic stresses such as drought and nutrient limitation. While setting out the state-of-the-art developments of biogeochemical and ecological modelling, we explore and highlight the role of plant diversity in the regulation of the ecosystem processes underlying the ecosystems services provided by multi-species grasslands. An extensive literature and model survey was carried out with an emphasis on technically advanced models reconciling biogeochemistry and biodiversity, which are readily applicable to managed grasslands in temperate latitudes. We propose a roadmap of promising developments in modelling.
Road to glory or highway to hell? Global road access and climate change mitigation
2020, Wenz, Leonie, Weddige, Ulf, Jakob, Michael, Steckel, Jan Christoph
Transportation infrastructure is considered a key factor for economic development and poverty alleviation. The United Nations have explicitly included the provision of transport infrastructure access, e.g. through all-season road access, in their Sustainable Development Goal agenda (SDGs, target 9.1). Yet, little is known about the number of people lacking access to roads worldwide, the costs of closing existing access gaps and the implications of additional roads for other sustainability concerns such as climate change mitigation (SDG-13). Here we quantify, for 250 countries and territories, the percentage of population without road access in 2 km. We find that infrastructure investments required to provide quasi-universal road access are about USD 3 trillion. We estimate that the associated cumulative CO2 emissions from construction work and additional traffic until the end of the century amount to roughly 16 Gt. Our geographically explicit global analysis provides a starting point for refined regional studies and for the quantification of further environmental and social implications of SDG-9.1.
Harmonization of global land use change and management for the period 850–2100 (LUH2) for CMIP6
2020, Hurtt, George C., Chini, Louise, Sahajpal, Ritvik, Frolking, Steve, Bodirsky, Benjamin L., Calvin, Katherine, Doelman, Jonathan C., Fisk, Justin, Fujimori, Shinichiro, Klein Goldewijk, Kees, Hasegawa, Tomoko, Havlik, Peter, Heinimann, Andreas, Humpenöder, Florian, Jungclaus, Johan, Kaplan, Jed O., Kennedy, Jennifer, Krisztin, Tamás, Lawrence, David, Lawrence, Peter, Ma, Lei, Mertz, Ole, Pongratz, Julia, Popp, Alexander, Poulter, Benjamin, Riahi, Keywan, Shevliakova, Elena, Stehfest, Elke, Thornton, Peter, Tubiello, Francesco N., van Vuuren, Detlef P., Zhang, Xin
Human land use activities have resulted in large changes to the biogeochemical and biophysical properties of the Earth's surface, with consequences for climate and other ecosystem services. In the future, land use activities are likely to expand and/or intensify further to meet growing demands for food, fiber, and energy. As part of the World Climate Research Program Coupled Model Intercomparison Project (CMIP6), the international community has developed the next generation of advanced Earth system models (ESMs) to estimate the combined effects of human activities (e.g., land use and fossil fuel emissions) on the carbon–climate system. A new set of historical data based on the History of the Global Environment database (HYDE), and multiple alternative scenarios of the future (2015–2100) from Integrated Assessment Model (IAM) teams, is required as input for these models. With most ESM simulations for CMIP6 now completed, it is important to document the land use patterns used by those simulations. Here we present results from the Land-Use Harmonization 2 (LUH2) project, which smoothly connects updated historical reconstructions of land use with eight new future projections in the format required for ESMs. The harmonization strategy estimates the fractional land use patterns, underlying land use transitions, key agricultural management information, and resulting secondary lands annually, while minimizing the differences between the end of the historical reconstruction and IAM initial conditions and preserving changes depicted by the IAMs in the future. The new approach builds on a similar effort from CMIP5 and is now provided at higher resolution (0.25∘×0.25∘) over a longer time domain (850–2100, with extensions to 2300) with more detail (including multiple crop and pasture types and associated management practices) using more input datasets (including Landsat remote sensing data) and updated algorithms (wood harvest and shifting cultivation); it is assessed via a new diagnostic package. The new LUH2 products contain > 50 times the information content of the datasets used in CMIP5 and are designed to enable new and improved estimates of the combined effects of land use on the global carbon–climate system.