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- ItemOpening up knowledge systems for better responses to global environmental change(Amsterdam [u.a.] : Elsevier, 2013) Cornell, S.; Berkhout, F.; Tuinstra, W.; Tà bara, J.D.; Jäger, J.; Chabay, I.; de Wit, B.; Langlais, R.; Mills, D.; Moll, P.; Otto, I.M.; Petersen, A.; Pohl, C.; van Kerkhoff, L.Linking knowledge with action for effective societal responses to persistent problems of unsustainability requires transformed, more open knowledge systems. Drawing on a broad range of academic and practitioner experience, we outline a vision for the coordination and organization of knowledge systems that are better suited to the complex challenges of sustainability than the ones currently in place. This transformation includes inter alia: societal agenda setting, collective problem framing, a plurality of perspectives, integrative research processes, new norms for handling dissent and controversy, better treatment of uncertainty and of diversity of values, extended peer review, broader and more transparent metrics for evaluation, effective dialog processes, and stakeholder participation. We set out institutional and individual roadmaps for achieving this vision, calling for well-designed, properly resourced, longitudinal, international learning programs.
- ItemTowards dynamical network biomarkers in neuromodulation of episodic migraine(Berlin : De Gruyter, 2013) Dahlem, M.A.; Rode, S.; May, A.; Fujiwara, N.; Hirata, Y.; Aihara, K.; Kurths, J.Computational methods have complemented experimental and clinical neurosciences and led to improvements in our understanding of the nervous systems in health and disease. In parallel, neuromodulation in form of electric and magnetic stimulation is gaining increasing acceptance in chronic and intractable diseases. In this paper, we firstly explore the relevant state of the art in fusion of both developments towards translational computational neuroscience. Then, we propose a strategy to employ the new theoretical concept of dynamical network biomarkers (DNB) in episodic manifestations of chronic disorders. In particular, as a first example, we introduce the use of computational models in migraine and illustrate on the basis of this example the potential of DNB as early-warning signals for neuromodulation in episodic migraine.
- ItemCorrelating the ancient Maya and modern european calendars with high-precision AMS 14C dating(London : Nature Publishing Group, 2013) Kennett, D.J.; Hajdas, I.; Culleton, B.J.; Belmecheri, S.; Martin, S.; Neff, H.; Awe, J.; Graham, H.V.; Freeman, K.H.; Newsom, L.; Lentz, D.L.; Anselmetti, F.S.; Robinson, M.; Marwan, N.; Southon, J.; Hodell, D.A.; Haug, G.H.The reasons for the development and collapse of Maya civilization remain controversial and historical events carved on stone monuments throughout this region provide a remarkable source of data about the rise and fall of these complex polities. Use of these records depends on correlating the Maya and European calendars so that they can be compared with climate and environmental datasets. Correlation constants can vary up to 1000 years and remain controversial.Wereport a series of high-resolution AMS14C dates on a wooden lintel collected from the Classic Period city of Tikal bearing Maya calendar dates. The radiocarbon dates were calibrated using a Bayesian statistical model and indicate that the dates were carved on the lintel betweenAD 658-696. This strongly supports the Goodman-Mart?nez-Thompson (GMT) correlation and the hypothesis that climate change played an important role in the development and demise of this complex civilization.