2015, Alebrahim, M.A., Krafft, C., Popp, J., El-Khateeb, Mohammad Y.

The structure and chemical features of the human dentin enamel junction (DEJ) were characterized using Raman spectroscopic imaging. Slices were prepared from 10 German, and 10 Turkish teeth. Raman images were collected at 785 nm excitation and the average Raman spectra were calculated for analysis. Univariate and multivariate spectral analysis were applied for investigation. Raman images were obtained based on the intensity ratios of CH at 1450 cm-1 (matrix) to phosphate at 960 cm-1 (mineral), and carbonate to phosphate (1070/960) ratios. Different algorithms (HCA, K-means cluster and VCA) also used to study the DEJ. The obtained results showed that the width of DEJ is about 5 pm related to univariate method while it varies from 6 to 12 μm based on multivariate spectral technique. Both spectral analyses showed increasing in carbonate content inside the DEJ compared to the dentin, and the amide I (collagen) peak in dentin spectra is higher than DEJ spectra peak.

2018, Campos, David, Pinho, Renato, Neugebauer, Ute, Popp, Juergen, Oliveira, José Luis, Zwiggelaar, Reyer, Gamboa, Hugo, Fred, Ana, Bermúdez i Badia, Sergi

Sepsis is still a little acknowledged public health issue, despite its increasing incidence and the growing mortality rate. In addition, a clear diagnosis can be lengthy and complicated, due to highly variable symptoms and non-specific criteria, causing the disease to be diagnosed and treated too late. This paper presents the HemoSpec platform, a decision support system which, by collecting and automatically processing data from several acquisition devices, can help in the early diagnosis of sepsis.

2014, Beev, N., Kiviranta, M., Van Der Kuur, J., Bruijn, M., Brandel, O., Linzen, S., Fritzsch, L., Ahoranta, J., Penttilä, J., Roschier, L.

We have demonstrated the operation of a 12-channel Beyer-style SQUID-based time domain multiplexer. It was manufactured using a fabrication process that is cross-compatible between VTT and IPHT-Jena. The multiplexer consists of twelve 12-SQUID series arrays, each shunted by a Zappe-style interferometer array acting as a flux-controlled superconducting/normal conducting switch. By keeping all switches but one in the superconducting state, it is possible to select one active readout channel at a time. A flux feedback coil common to all SQUID arrays allows realization of a flux-locked loop. We present characteristics of the multiplexer and measurement data from experiments with a 25-pixel X-ray calorimeter array operated at T < 100 mK in a dilution refrigerator.

2017, Prikhna, Tetiana, Romaka, Vitaliy, Eisterer, Michael, Shapovalov, Andrii, Kozyrev, Artem, Grechnev, Gennadiy, Boutko, Viktor, Goldacker, Wilfried, Habisreuther, Tobias, Vakaliuk, Oleksii, Halbedel, Bernd

An x-ray analysis of MgB2-based materials shows that they contain MgB2 and MgO phases. According to a quantitative Auger analysis (taken after removing the oxidized surface layer by Ar ion etching in the microscope chamber) the MgB2 phase contains some amount of oxygen that approximately corresponds to the composition MgB2.2-1.7O0.4-0.6. Rietveld refinement of the MgB2 phase, based on EDX data with varying B/O content, leads to the composition MgB1.68-1.8O0.2-0.32. Ab-initio modelling of boron substitution by oxygen in MgB2 (ΔH f = -150.6 meV/atom) shows that this is energetically favourable up to the composition MgB1.75O0.25 (ΔH f = -191.4 meV/atom). In contrast to carbon substitution, where very small levels of doping can dramatically affect the superconducting characteristics of the material with concomitant changes in the electron density, oxygen substitution results in very little change in the superconducting properties of MgB2. The formation of vacancies at the Mg site of both MgB2 and substituted MgB1.75O0.25 was modelled as well, but has shown that such processes are energetically disadvantageous (ΔHf of Mg0.875B2 and Mg0.75B1.75O0.25 are equal to -45.5 and -93.5 meV/atom, respectively).

2019, Pradhan, Pranita, Meyer, Tobias, Vieth, Michael, Stallmach, Andreas, Waldner, Maximilian, Schmitt, Michael, Popp, Juergen, Bocklitz, Thomas, De Marsico, Maria, Sanniti di Baja, Gabriella, Fred, Ana

Non-linear multimodal imaging, the combination of coherent anti-stokes Raman scattering (CARS), two-photon excited fluorescence (TPEF) and second harmonic generation (SHG), has shown its potential to assist the diagnosis of different inflammatory bowel diseases (IBDs). This label-free imaging technique can support the ‘gold-standard’ techniques such as colonoscopy and histopathology to ensure an IBD diagnosis in clinical environment. Moreover, non-linear multimodal imaging can measure biomolecular changes in different tissue regions such as crypt and mucosa region, which serve as a predictive marker for IBD severity. To achieve a real-time assessment of IBD severity, an automatic segmentation of the crypt and mucosa regions is needed. In this paper, we semantically segment the crypt and mucosa region using a deep neural network. We utilized the SegNet architecture (Badrinarayanan et al., 2015) and compared its results with a classical machine learning approach. Our trained SegNet mod el achieved an overall F1 score of 0.75. This model outperformed the classical machine learning approach for the segmentation of the crypt and mucosa region in our study.

2018, Salakhova, R.T., Vylegzhanin, A. G., Kashtanov, E.A., Zverev, V.I., Müller, R., de Sena Pereira, F.D., Parfenov, V.A., Mironov, V.A., Kritskaya, E.A., Pyatakov, A.P., Markov, V.K., Malyshev, A.Yu, Kamilov, K.I, Tishin, A.M, Perov, N., Semisalova, A.

Heating of the magnetic nanoparticles in AC magnetic field is the effect promising for application in medicine. The mechanisms of heating in AC-magnetic field implies nontrivial dependence of the power dissipated by magnetic nanoparticles on frequency. With the use of a reconfigurable experimental setup, this frequency-dependent magnetic heating was measured on two characteristic examples: the magnetite nanoparticles conventionally used in medicine and polymer coating with micrometer sized magnetite particles. The saturation of the heating power with frequency is shown that is more pronounced for the second case of microparticles.

2012, Prikhna, T., Gawalek, W., Eisterer, M., Weber, H.W., Noudem, J., Sokolovsky, V., Chaud, X., Moshchil, V., Karpets, M., Kovylaev, V., Borimskiy, A., Tkach, V., Kozyrev, A., Kuznietsov, R., Dellith, J., Shmidt, C., Basyuk, T., Litzkendorf, D., Karau, F., Dittrich, U., Tomsic, M.

Structures of MgB2-based materials manufactured under pressure (up to 2 GPa) by different methods having high superconducting performance and connectivity are multiphase and contain different Mg-B-O compounds. Some oxygen can be incorporated into MgB2 and boron into MgO structures, MgBx (X=4-20) inclusions contain practically no oxygen. Regulating manufacturing temperature, pressure, introducing additions one can influence oxygen and boron distribution in the materials and thus, affect the formation, amount and sizes of Mg-B-O and MgBx inclusions and changing type of pinning, pinning force and so affect critical current density jc. The boron concentration increase in initial Mg and B mixture allows obtaining sample containing 88.5 wt% of MgB12 with Tc of 37.4 K (estimated magnetically).

2016, Vetter, Michael, Gawlik, Annett, Plentz, Jonathan, Andrä, Gudrun, Ribeyron, Pierre-Jean, Cuevas, Andres, Weeber, Arthur, Ballif, Christophe, Glunz, Stefan, Poortmans, Jef, Brendel, Rolf, Aberle, Armin, Sinton, Ron, Verlinden, Pierre, Hahn, Giso

Liquid-phase crystallized silicon on glass (LPCSG) presents a promising material to fabricate high quality silicon thin films, e.g. for solar cells and modules. Barrier layers and a doped amorphous silicon layer are deposited on the glass substrate followed by crystallization with a line focus laser beam. In this paper we introduce injection level dependent lifetime measurements generated by the quasi steady-state photoconductance decay method (QSSPC) to characterize LPCSG absorbers. This contactless method allows a determination of the LPCSG absorber quality already at an early stage of solar cell fabrication, and provides a monitoring of the absorber quality during the solar cell fabrication steps. We found minority carrier lifetimes higher than 200ns in our layers (e.g. n-type absorber with ND=2x1015cm-3) indicating a surface recombination velocity SBL<3000cm/s at the barrier layer/Si interface.

2014, Reiche, M., Kittler, M., Schmelz, M., Stolz, R., Pippel, E., Uebensee, H., Kermann, M., Ortlepp, T.

Low-temperature measurements proved the existence of a two-dimensional electron gas at defined dislocation arrays in silicon. As a consequence, single-electron transitions (Coulomb blockades) are observed. It is shown that the high strain at dislocation cores modifies the band structure and results in the formation of quantum wells along dislocation lines. This causes quantization of energy levels inducing the formation of Coulomb blockades.

2016, Mehner, H., Müller, L., Biermann, S., Hänschke, F., Hoffmann, M.

The process flow to integrate metallic nanostructures in surface micromachining processes is presented. The nanostructures are generated by evaporation of microstructured silicon grass with metal. The process flow is based on the lift-off of a thin amorphous silicon layer deposited using a CVD process. All steps feature a low temperature load beneath 120 °C and high compatibility with many materials as only well-established chemicals are used. As a result metallic nanostructures usable for optical applications can be generated as part of multilayered microsystems fabricated in surface micromachining.