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End date: 2021 × Start date: 2021 × Publisher: Cambridge : RSC × Subject: Amides × WGL Institute: LIKAT ×

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    Pd/Cu-Catalyzed amide-enabled selectivity-reversed borocarbonylation of unactivated alkenes
    (Cambridge : RSC, 2021) Wu, Fu-Peng; Wu, Xiao-Feng
    The addition reaction between CuBpin and alkenes to give a terminal boron substituted intermediate is usually fast and facile. In this communication, a selectivity-reversed procedure has been designed and established. This selectivity-reversed borocarbonylation reaction is enabled by a cooperative action between palladium and copper catalysts and proceeds with complete regioselectivity. The key to the success of this transformation is the coordination of the amide group and slower CuBpin formation by using KHCO3as the base. A wide range of β-boryl ketones were produced from terminal unactivated aliphatic alkenes and aryl iodides. Further synthetic transformations of the obtained β-boryl ketones have been developed as well. © The Royal Society of Chemistry 2021.
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    A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation
    (Cambridge : RSC, 2021) Li, Yang; Zhang, Cai-Lin; Huang, Wei-Heng; Sun, Ning; Hao, Meng; Neumann, Helfried; Beller, Matthias
    β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. Here, we report a novel one-step approach for the synthesis of α-(trifluoromethyl)-β-lactams and related products from fluorinated olefins, anilines and CO. Utilization of an advanced palladium catalyst system with the Ruphos ligand allows for selective cycloaminocarbonylations to give diverse fluorinated β-lactams in high yields. © The Royal Society of Chemistry 2021.