Filters

2016 - 201922020 - 20211

More filters

2022 - 20233
Reset filters

Settings

End date: 2021 × DDC: 530 × Type: Text × Publisher: Bristol : IOP Publ. × Subject: plasma medicine × WGL Institute: INP ×

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Concepts and characteristics of the ‘COST Reference Microplasma Jet’
    (Bristol : IOP Publ., 2016) Golda, J.; Held, J.; Redeker, B.; Konkowski, M.; Beijer, P.; Sobota, A.; Kroesen, G.; Braithwaite, N.S.J.; Reuter, S.; Turner, M.M.; Gans, T.; O’Connell, D.; Schulz-von der Gathen, V.
    Biomedical applications of non-equilibrium atmospheric pressure plasmas have attracted intense interest in the past few years. Many plasma sources of diverse design have been proposed for these applications, but the relationship between source characteristics and application performance is not well-understood, and indeed many sources are poorly characterized. This circumstance is an impediment to progress in application development. A reference source with well-understood and highly reproducible characteristics may be an important tool in this context. Researchers around the world should be able to compare the characteristics of their own sources and also their results with this device. In this paper, we describe such a reference source, developed from the simple and robust micro-scaled atmospheric pressure plasma jet (μ-APPJ) concept. This development occurred under the auspices of COST Action MP1101 'Biomedical Applications of Atmospheric Pressure Plasmas'. Gas contamination and power measurement are shown to be major causes of irreproducible results in earlier source designs. These problems are resolved in the reference source by refinement of the mechanical and electrical design and by specifying an operating protocol. These measures are shown to be absolutely necessary for reproducible operation. They include the integration of current and voltage probes into the jet. The usual combination of matching unit and power supply is replaced by an integrated LC power coupling circuit and a 5 W single frequency generator. The design specification and operating protocol for the reference source are being made freely available.
  • Thumbnail Image
    Item
    The kINPen—a review on physics and chemistry of the atmospheric pressure plasma jet and its applications
    (Bristol : IOP Publ., 2018-5-16) Reuter, Stephan; von Woedtke, Thomas; Weltmann, Klaus-Dieter
    The kINPen® plasma jet was developed from laboratory prototype to commercially available non-equilibrium cold plasma jet for various applications in materials research, surface treatment and medicine. It has proven to be a valuable plasma source for industry as well as research and commercial use in plasma medicine, leading to very successful therapeutic results and its certification as a medical device. This topical review presents the different kINPen plasma sources available. Diagnostic techniques applied to the kINPen are introduced. The review summarizes the extensive studies of the physics and plasma chemistry of the kINPen performed by research groups across the world, and closes with a brief overview of the main application fields.
  • Thumbnail Image
    Item
    Influence of aerosol injection on the liquid chemistry induced by an RF argon plasma jet
    (Bristol : IOP Publ., 2021) Sremački, Ivana; Bruno, Giuliana; Jablonowski, Helena; Leys, Christophe; Nikiforov, Anton; Wende, Kristian
    A radio-frequency driven plasma jet in annular geometry coupled with an aerosol injection into the effluent is proposed for the controllable reactive oxygen species (ROS)/reactive nitrogen species (RNS) production and delivery on biological targets in the context of plasma medicine, e.g. wound care. The role of the aqueous aerosol in modulating the reactive species production is investigated by combining physical and chemical analytics. Optical emission spectroscopy, electron paramagnetic resonance spectroscopy, and a biochemical model based on cysteine as a tracer molecule have been applied, revealing that aerosol injection shifts the production of ROS from atomic and singlet oxygen toward hydroxyl radicals, which are generated in the droplets. Species generation occurred mainly at the droplets boundary layer during their transport through the effluent, leading to a limited cysteine turnover upon introduction into the aerosol solution. The subsequent delivery of unmodified cysteine molecules at a target suggested the application of the plasma source for the topical delivery of drugs, expanding the potential applicability and effectiveness. The presence of RNS was negligible regardless of aerosol injection and only traces of the downstream products nitrate and nitrate were detected. In summary, the aerosol injection into the effluent opens new avenues to control UV radiation and reactive species output for the biomedical applications of non-thermal plasma sources, reaching out toward the regulation, safety, and efficacy of targeted applications.