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- ItemAmphiphilic Copolymers for Versatile, Facile, and In Situ Tunable Surface Biofunctionalization(Weinheim : Wiley-VCH, 2021) Ruland, André; Schenker, Saskia; Schirmer, Lucas; Friedrichs, Jens; Meinhardt, Andrea; Schwartz, Véronique B.; Kaiser, Nadine; Konradi, Rupert; MacDonald, William; Helmecke, Tina; Sikosana, Melissa K.L.N.; Valtin, Juliane; Hahn, Dominik; Renner, Lars D.; Werner, Carsten; Freudenberg, UwePrecision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials-which is why they are referred to as "anchor polymers" (APs)-and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives-including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials-APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodisplacement of adsorbed APs provide unprecedented means of in situ alteration and renewal of the functionalized surfaces. The related options are exemplified with proof-of-concept experiments of controlled bacterial adhesion, human umbilical vein endothelial cell, and induced pluripotent cell growth on AP-functionalized surfaces.