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Start date: 2010 × Publisher: Hannover : Technische Informationsbibliothek ×

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Now showing 1 - 10 of 61
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    Prozessmikrobiologie in landwirtschaftlichen Biogasanlagen : Ermittlung der mikrobiellen Diversität sowie von hauptsächlichen verfahrenstechnischen Einflussfaktoren auf die Mikroflora : Schlussbericht zum Forschungsverbund BIOGAS-BIOCOENOSIS : Laufzeit: 01.11.2011 bis 31.10.2013
    (Hannover : Technische Informationsbibliothek, 2014) Theuerl, Susanne; Klocke, Michael; Maus, Irene; Schlüter, Andreas; Benndorf, Dirk; Kohrs, Fabian; Hitzmann, Bernd; Beltramo, Tetyana
    [no abstract available]
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    Genealogical properties of spatial models in Population Genetics
    (Hannover : Technische Informationsbibliothek, 2023-09) Wirtz, Johannes
    At the interface between Phylo- and Population Genetics, and recently heavily inspired by Epidemonology, the discipline of Phylogeography comprises modelling techniques from classical theoretical biology and combines them with a spatial (2D or 3D) aspect, with the purpose of utilizing geographical information in the analysis to understand the evolutionary history of a biological system or aspects of virology such as directionality and seasonality in pandemic outbreaks [1, 2, 3, 4]. An prime example of this are datasets that take into account the sampling locations of its components (geo-referenced genomic data). In this project, we have focused on the model called "spatial Lambda-Fleming-Viot process" ( V [5, 6]) and analzed its statistical properties forward in time as well as in the ancestral (dual) process, with results that may be used for parameter inference. Of particlar interest was the spatial variance, denoted , a parameter controlling the speed at which genetic information is spread across space and therefore an analog of the reproduction number (R0) used in epidemonology e.g. to assess the infectiousness of differing viral strains. We explored the relation of this parameter to the time to coalescence between lineage pairs in this model and described methods of estimating it from sampled data under different circumstances. We have furthermore investigated similarities and differences between this model and classical models in Population Genetics, particularly Birth-Death processes, which are heavily used for all kinds of biological inference problems, but do not by themselves feature a spatial component. We compared the Vto a variant of the Birth-Death process where the location of a live individual changes over the course of its lifetime according to a Brownian motion. This process is not as easily viewed backward in time as the V, but the genalogical process is accessible by Markov-Chain Monte Carlosimulation, as the likelihoods of ancestral positions and branch lengths are easily calculated, making this model easily applicable to data. Our analysis highlights the analogy between the two processes forward in time as well as backward in time; on the other hand, we also observed a divergent behavior of the two models when no prior on the phylogenetic time scale was assumed. Lastly, this project has given rise to a study of combinatorial properties of tree shapes relevant to the V, the Birth-Death and other biological processes. In particular, we were able to identify the combinatorial class genealogical trees generated from these processes belong to and verify a conjecture regarding their enumeration. Preliminary versions of software tools for the aforementioned inference have also been provided.
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    An Empirical Study on 3D Artefacts in the Scientific Life Cycle
    (Hannover : Technische Informationsbibliothek, 2018) Struß, J.M.
    3D models, objects and data are being used in an increasing number of scientific disciplines throughout different points in the research life cycle. In addition to architecture, civil engineering and mechanical engineering – disciplines that traditionally plan and construct in three-dimensional space – they are also used in the fields of electrical engineering and information technology, physics and astronomy as well as in the conservation of cultural heritage. The types of models used differ considerably in the different disciplines. In addition to CAD models, there are for example formats such as point clouds resulting from laser scans, which are used to capture buildings or landscapes. In addition, there are simulations in which the temporal dimension also plays a role. Furthermore printable 3D models that allow the direct generation of a physical object are increasingly being created. The study presented here takes a closer look at the diversity of 3D artefacts, the point of their creation in the research lifecycle as well as the purpose these artefacts serve.
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    Lizenzierung von AV-Medien in Deutschland
    (Hannover : Technische Informationsbibliothek, 2017) Brehm, Elke
    Zunehmend werden auch im wissenschaftlichen Kontext Filme publiziert. Damit müssen Möglichkeiten geschaffen werden diese Filme auch in wissenschaftlichen Online-Portalen anzubieten. Ziel des Kompetenzzentrums für nichttextuelle Materialien der TIB ist es unter anderem, wissenschaftliche audiovisuelle Medien zu sammeln, zu archivieren und über das TIB AV Portal Nutzern online zur Verfügung zu stellen. Die Filme werden inhaltlich erschlossen und durch Vergabe von DOIs sekundengenau referenzierbar gemacht. Die Sammlung und der Erwerb der notwendigen Rechte ist im Hinblick auf die Rechtslage an Filmen komplex, insbesondere im Online-Kontext. Einerseits ist der Markt für wissenschaftliche Informationen international und endet nicht an nationalen Grenzen. Es besteht keine Möglichkeit von Verwertungsgesellschaften Lizenzen für ganze Sammlungen zu erwerben. Dadurch steht die TIB vor der Herausforderung die Filme bei den einzelnen Rechteinhabern zu lizenzieren und bei bereits vorhandenen Sammlungen Rechte ggfls. nachzulizenzieren (Sammlung des IWF- Wissen und Medien gGmbH i. L.) damit die Filme über das TIB AV Portal angeboten werden können. In dieser Präsentation werden der rechtliche Rahmen und unter Einbezug der Praxis zum Umgang mit verwaisten Werken die Herausforderungen dargestellt, die sich in der Praxis bei der Sammlung und Online-Bereitstellung von wissenschaftlichen Filmen stellen.
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    Bridging the Gap Between (AI-) Services and Their Application in Research and Clinical Settings Through Interoperability: the OMI-Protocol
    (Hannover : Technische Informationsbibliothek, 2024-02) Sigle, Stefan; Werner, Patrick; Schweizer, Simon; Caldeira, Liliana; Hosch, René; Dyrba, Martin; Fegeler, Christian; Sigle, Stefan; Werner, Patrick; Schweizer, Simon; Caldeira, Liliana; Hosch, René; Dyrba, Martin; Fegeler, Christian; Grönke, Ana; Seletkov, Dmitrii; Kotter, Elmar; Nensa, Felix; Wehrle, Julius; Kaufmes, Kevin; Scherer, Lucas; Nolden, Marco; Boeker, Martin; Schmidt, Marvin; Pelka, Obioma; Braren, Rickmer; Stump, Shura-Roman; Graetz, Teresa; Pogarell, Tobias; Susetzky, Tobias; Wieland, Tobias; Parmar, Vicky; Wang, Yuanbin
    Artificial Intelligence (AI) in research and clinical contexts is transforming the areas of medical and life sciences permanently. Aspects like findability, accessibility, interoperability, and reusability are often neglected for AI-based inference services. The Open Medical Inference (OMI) protocol aims to support remote inference by addressing the aforementioned aspects. Key component of the proposed protocol is an interoperable registry for remote inference services, which addresses the issue of findability for algorithms. It is complemented by information on how to invoke services remotely. Together, these components lay the basis for the implementation of distributed inference services beyond organizational borders. The OMI protocol considers prior work for aspects like data representation and transmission standards wherever possible. Based on Business Process Modeling of prototypical use cases for the service registry and common inference processes, a generic information model for remote services was inferred. Based on this model, FHIR resources were identified to represent AI-based services. The OMI protocol is first introduced using AI-services in radiology but is designed to be generalizable to other application domains as well. It provides an accessible, open specification as blueprint for the introduction and implementation of remote inference services.
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    Wie helfen Blockchain und P2P in Bildung, Forschung, Kulturerbe?
    (Hannover : Technische Informationsbibliothek, 2018) Heller, Lambert
    [no abstract available]
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