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- ItemDas Freiburger Magisterdiplom für den Pharmazeuten Johann Christoph Friedrich Weissmann (revidierte und vermehrte Fassung)(Tübingen : Universitätsbibliothek Tübingen, 2023) Diebold, Steffen M.Bei dem hier wiedergegebenen Diplom für einen Apotheker handelt es sich um eine handschriftliche Urkunde vom 16. Juni 1803 aus Freiburg im Breisgau, der damals bedeutendsten Stadt in Vorderösterreich. Der pharmaziehistorisch interessante Schriftsatz bietet ein Beispiel universitären Verwaltungshandelns zum Ende des Alten Reichs, des Heiligen Römischen Reichs Deutscher Nation (Sacrum Imperium Romanum Nationis Germaniae). Auf eine kurze Beschreibung der lateinischen Urkunde (Diplomatik) folgt eine (textnahe Gebrauchs-) Übersetzung durch den Autor.
- ItemCorona - Wahn oder Wissenschaft? (Plädoyer für Vernunft)(Nürnberg : Gesellschaft für Kritische Philosophie GKP, 2022-10) Diebold, Steffen M.The corona pandemic poses major challenges for society. Many people lack (basic) scientific knowledge. They are skeptical and distrust research principles and concepts. Esotericism and (super) belief replace their access to reality. Not only facts are recently "alternative". Pseudo-scientific healing methods and occult procedures have long been presented to the public as equivalent alternatives to modern medicine, despite the lack of evidence of their effectiveness. Just as if reason or nonsense were just a question of personal taste, a different world view. Seconded by talk of an "exaggeratedly scientific world view", empiricism and logic were systematically defamed. As a result of this distorted picture, all kinds of conspiracy theories are now rampant. Spiritual healers, seers, shamans, charlatans, quacks, sectarians, and zealots of all stripes and persuasions are in demand. A diffuse pandemic management and miserable communication do the rest and contribute to the fact that infection control measures are often flatly rejected and vaccination rates can hardly be increased significantly.
- ItemPhysiological Parameters Relevant to Dissolution Testing - Hydrodynamic Considerations (rev. and suppl. version)(Tübingen : Universitätsbibliothek Tübingen, 2023) Diebold, Steffen M.The first two sections of the monograph present an introduction into basic hydrodynamics relevant to in vitro dissolution testing including V. G. Levichs convective diffusion theory and the authors combination model. This part is followed by hydrodynamic considerations of in vivo dissolution including hydrodynamic problems inherent to in vivo bioavailability of solid oral dosage forms. Hydrodynamics in the upper GI tract contribute to in vivo dissolution. Our ability to forecast dissolution of poorly soluble drugs in vitro depends on our knowledge of and ability to control hydrodynamics as well as other factors influencing dissolution. Provided suitable conditions (apparatus, hydrodynamics, media) are chosen for the dissolution test, it seems possible to predict dissolution limitations to the oral absorption of drugs and to reflect variations in hydrodynamic conditions in the upper GI tract. The fluid volume available for dissolution in the gut lumen, the contact time of the dissolved compound with the absorptive sites and the particle size have been identified as the main hydrodynamic determinants for the absorption of poorly soluble drugs in vivo. The influence of these factors is usually more pronounced than that of the motility pattern or the gastrointestinal flow rates per se.
- ItemDimensionsanalyse für Ingenieure : Dimensionstheoretische Grundlagen und Anwendungsbeispiele(Hannover : Technische Informationsbibliothek, 2023) Kleinschmidt, WalterDer vorliegende Text stellt eine Überarbeitung und Erweiterung der Vorlesungsunterlagen dar, die der Verfasser während seiner früheren Lehrtätigkeit im Fachbereich Maschinentechnik der Universität Siegen erstellt hat. Dabei liegt der Schwerpunkt auf den für Ingenieure interessanten vielfältigen und teilweise umfänglichen Anwendungsbeispielen zur Dimensionsanalyse. Diese zweite Version v2 des Textes enthält einige Präzisierungen und weitere Anwendungsbeispiele.
- ItemComposite forming simulation for non-crimp fabrics based on generalized continuum approaches – AMECOMP : Abschlussbericht / Final project report (DFG 431354059 / ANR-19-CE06-0031)(Hannover : Technische Informationsbibliothek, 2024-05) Schäfer, Bastian; Kärger, Luise; Naouar, Naim; Zheng, Ruochen; Schäfer, Bastian; Kärger, Luise; Naouar, Naim; Zheng, Ruochen; Boisse, Philippe; Colmars, Julien; Platzer, AurianeContinuously carbon fiber reinforced composites are increasingly used for structural applications in various fields of engineering due to their excellent weight-specific mechanical properties. Non-crimp-fabrics (NCF) provide the highest lightweight potential as reinforcement for the composite due to their straight fibers, compared to woven fabrics with undulated fibers. NCFs are made of one (UD-NCF), two (Biax-NCF) or more directions of fibers linked together with a polymer stitching in specific patterns. The deformation behavior of NCFs is challenging due to the interaction between the fibers and the stitching, which also results in a higher susceptibility to forming effects such as roving slippage, fiber waviness and gapping compared to woven fabrics. The aim of the AMECOMP project was to improve the understanding of the forming behavior of NCFs and to develop suitable simulation models to broaden the range of potential applications. Mesoscopic models that accurately describe the architecture of the NCF were developed for virtual material characterization and detailed analysis of forming defects in critical areas. Macroscopic models that describe the relevant deformation mechanisms of NCF in a homogenized way were developed for efficient analysis of large components and multi-layer stacks.