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- ItemPerformance of seasonal forecasts for the flowering and veraison of two major Portuguese grapevine varieties(Amsterdam [u.a.] : Elsevier, 2023) Yang, Chenyao; Ceglar, Andrej; Menz, Christoph; Martins, Joana; Fraga, Helder; Santos, João A.Seasonal phenology forecasts are becoming increasingly demanded by winegrowers and viticulturists. Forecast performance needs to be investigated over space and time before practical applications. We assess seasonal forecast performance (skill, probability and accuracy) in predicting flowering and veraison stages of two representative varieties in Portugal over 1993–2017. The state-of-the-art forecast system ECMWF-SEAS5 provides 7-month seasonal forecasts and is coupled with a locally adapted phenology model. Overall, findings illustrate the dependence of forecast performance on initialization timings, regions and predicting subjects (stages and varieties). Forecast performance improves by delaying the initialization timing and only forecasts initialized on April 1st show better skills than climatology on predicting phenology terciles (early/normal/late). The considerable bias of daily values of seasonal climate predictions can represent the main barrier to accurate forecasts. Better prediction performance is consistently found in Central-Southern regions compared to Northern regions, attributing to an earlier phenology occurrence with a shorter forecast length. Comparable predictive skills between flowering and veraison for both varieties imply better predictability in summer. Consequently, promising seasonal phenology predictions are foreseen in Central-Southern wine regions using forecasts initialized on April 1st with approximately 1–2/3–4 months lead time for flowering/veraison: potential prediction errors are ∼2 weeks, along with an overall moderate forecast skill on categorical events. However, considerable inter-annual variability of forecast performance over the same classified phenology years reflects the substantial influence of climate variability. This may represent the main challenge for reliable forecasts in Mediterranean regions. Recommendations are suggested for methodological innovations and practical applications towards reliable regional phenology forecasts.
- ItemA review of coarse mineral dust in the Earth system(Amsterdam [u.a.] : Elsevier, 2022) Adebiyi, Adeyemi; Kok, Jasper F.; Murray, Benjamin J.; Ryder, Claire L.; Stuut, Jan-Berend W.; Kahn, Ralph A.; Knippertz, Peter; Formenti, Paola; Mahowald, Natalie M.; Pérez García-Pando, Carlos; Klose, Martina; Ansmann, Albert; Samset, Bjørn H.; Ito, Akinori; Balkanski, Yves; Di Biagio, Claudia; Romanias, Manolis N.; Huang, Yue; Meng, JunMineral dust particles suspended in the atmosphere span more than three orders of magnitude in diameter, from <0.1 µm to more than 100 µm. This wide size range makes dust a unique aerosol species with the ability to interact with many aspects of the Earth system, including radiation, clouds, hydrology, atmospheric chemistry, and biogeochemistry. This review focuses on coarse and super-coarse dust aerosols, which we respectively define as dust particles with a diameter of 2.5–10 µm and 10–62.5 µm. We review several lines of observational evidence indicating that coarse and super-coarse dust particles are transported farther than previously expected and that the abundance of these particles is substantially underestimated in current global models. We synthesize previous studies that used observations, theories, and model simulations to highlight the impacts of coarse and super-coarse dust aerosols on the Earth system, including their effects on dust-radiation interactions, dust-cloud interactions, atmospheric chemistry, and biogeochemistry. Specifically, coarse and super-coarse dust aerosols produce a net positive direct radiative effect (warming) at the top of the atmosphere and can modify temperature and water vapor profiles, influencing the distribution of clouds and precipitation. In addition, coarse and super-coarse dust aerosols contribute a substantial fraction of ice-nucleating particles, especially at temperatures above –23 °C. They also contribute a substantial fraction to the available reactive surfaces for atmospheric processing and the dust deposition flux that impacts land and ocean biogeochemistry by supplying important nutrients such as iron and phosphorus. Furthermore, we examine several limitations in the representation of coarse and super-coarse dust aerosols in current model simulations and remote-sensing retrievals. Because these limitations substantially contribute to the uncertainties in simulating the abundance and impacts of coarse and super-coarse dust aerosols, we offer some recommendations to facilitate future studies. Overall, we conclude that an accurate representation of coarse and super-coarse properties is critical in understanding the impacts of dust aerosols on the Earth system.
- ItemCurvature model for nanoparticle size effects on peptide fibril stability and molecular dynamics simulation data(Amsterdam [u.a.] : Elsevier, 2022) John, Torsten; Martin, Lisandra L.; Risselada, Herre Jelger; Abel, BerndNanostructured surfaces are widespread in nature and are being further developed in materials science. This makes them highly relevant for biomolecules, such as peptides. In this data article, we present a curvature model and molecular dynamics (MD) simulation data on the influence of nanoparticle size on the stability of amyloid peptide fibrils related to our research article entitled “Mechanistic insights into the size-dependent effects of nanoparticles on inhibiting and accelerating amyloid fibril formation” (John et al., 2022) [1]. We provide the code to perform MD simulations in GROMACS 4.5.7 software of arbitrarily chosen biomolecule oligomers adsorbed on a curved surface of chosen nanoparticle size. We also provide the simulation parameters and data for peptide oligomers of Aß40, NNFGAIL, GNNQQNY, and VQIYVK. The data provided allows researchers to further analyze our MD simulations and the curvature model allows for a better understanding of oligomeric structures on surfaces.
- ItemDataset on permeability of wings from owls and non-silently flying birds(Amsterdam [u.a.] : Elsevier, 2024) Geyer, Thomas F.; Windisch, Thomas; Fritzsche, Christoph; Sarradj, EnnesThe very soft and flow-permeable plumage is among the special adaptations of the owl that the silent flight is attributed to. Using a specially designed apparatus that provides a low-speed volume flow of air through a small sample of porous material, measurements of the air flow permeability were performed in accordance to ISO 9053 on a total of 39 prepared wing specimen from six different bird species, including three species of silently flying owls and three non-silently flying bird species. The resulting data set described in the present paper contains the static airflow resistance measured at different positions on the wing.
- ItemGrain-size distribution dataset of supercritical flow sediments from a Gilbert-type delta that are associated with disaggregation bands(Amsterdam [u.a.] : Elsevier, 2022) Tanner, David C.; Brandes, Christian; Winsemann, JuttaThis is a dataset of grain-size distribution in sub- and supercritical flow sediments of a Gilbert-type delta from an outcrop in North Germany. Thirteen samples of ca 2.5 kg were dried (at 105°C), and homogenised twice with a sample divider. A representative sample of 1-2 g was then analysed using laser diffraction. The grain-size distribution of the sand has a maximum between fine to medium sand, with a long fine fraction tail down to 0.06 µm and occasional coarse fractions (up to 1.5 mm) in some samples. Specific grain-size distributions correlate with the different sedimentary bedforms from which the samples were taken. This data is important for two reasons: Firstly, sedimentary structures formed by Froude supercritical flows are controlled by grain-size. However, few studies have provided grain-size datasets from the natural record, which often have a much wider grain-size distribution than experimentally-produced supercritical flow deposits. Secondly, the sands were deformed subsequently by disaggregation bands, a type of geological fault that only develops in porous granular materials, i.e. well-sorted, medium sand. The disaggregation bands are indicative of seismic or even aseismic, creeping movement of basement faults.
- ItemPS-BBICS: Pulse stretching bulk built-in current sensor for on-chip measurement of single event transients(Amsterdam [u.a.] : Elsevier, 2022) Andjelkovic, Marko; Marjanovic, Milos; Chen, Junchao; Ilic, Stefan; Ristic, Goran; Krstic, MilosThe bulk built-in current sensor (BBICS) is a cost-effective solution for detection of energetic particle strikes in integrated circuits. With an appropriate number of BBICSs distributed across the chip, the soft error locations can be identified, and the dynamic fault-tolerant mechanisms can be activated locally to correct the soft errors in the affected logic. In this work, we introduce a pulse stretching BBICS (PS-BBICS) constructed by connecting a standard BBICS and a custom-designed pulse stretching cell. The aim of PS-BBICS is to enable the on-chip measurement of the single event transient (SET) pulse width, allowing to detect the linear energy transfer (LET) of incident particles, and thus assess more accurately the radiation conditions. Based on Spectre simulations, we have shown that for the LET from 1 to 100 MeV cm2 mg−1, the SET pulse width detected by PS-BBICS varies by 620–800 ps. The threshold LET of PS-BBICS increases linearly with the number of monitored inverters, and it is around 1.7 MeV cm2 mg−1 for ten monitored inverters. On the other hand, the SET pulse width is independent of the number of monitored inverters for LET > 4 MeV cm2 mg−1. It was shown that supply voltage, temperature and process variations have strong impact on the response of PS-BBICS.
- ItemPrecise Laplace asymptotics for singular stochastic PDEs: The case of 2D gPAM(Amsterdam [u.a.] : Elsevier, 2022) Friz, Peter K.; Klose, TomWe implement a Laplace method for the renormalised solution to the generalised 2D Parabolic Anderson Model (gPAM) driven by a small spatial white noise. Our work rests upon Hairer's theory of regularity structures which allows to generalise classical ideas of Azencott and Ben Arous on path space as well as Aida and Inahama and Kawabi on rough path space to the space of models. The technical cornerstone of our argument is a Taylor expansion of the solution in the noise intensity parameter: We prove precise bounds for its terms and the remainder and use them to estimate asymptotically irrevelant terms to arbitrary order. While most of our arguments are not specific to gPAM, we also outline how to adapt those that are.
- ItemClimate change impacts on European arable crop yields: Sensitivity to assumptions about rotations and residue management(Amsterdam [u.a.] : Elsevier, 2022) Faye, Babacar; Webber, Heidi; Gaiser, Thomas; Müller, Christoph; Zhang, Yinan; Stella, Tommaso; Latka, Catharina; Reckling, Moritz; Heckelei, Thomas; Helming, Katharina; Ewert, FrankMost large scale studies assessing climate change impacts on crops are performed with simulations of single crops and with annual re-initialization of the initial soil conditions. This is in contrast to the reality that crops are grown in rotations, often with sizable proportion of the preceding crop residue to be left in the fields and varying soil initial conditions from year to year. In this study, the sensitivity of climate change impacts on crop yield and soil organic carbon to assumptions about annual model re-initialization, specification of crop rotations and the amount of residue retained in fields was assessed for seven main crops across Europe. Simulations were conducted for a scenario period 2040–2065 relative to a baseline from 1980 to 2005 using the SIMPLACE1 framework. Results indicated across Europe positive climate change impacts on yield for C3 crops and negative impacts for maize. The consideration of simulating rotations did not have a benefit on yield variability but on relative yield change in response to climate change which slightly increased for C3 crops and decreased for C4 crops when rotation was considered. Soil organic carbon decreased under climate change in both simulations assuming a continuous monocrop and plausible rotations by between 1% and 2% depending on the residue management strategy.
- ItemMedical gas plasma augments bladder cancer cell toxicity in preclinical models and patient-derived tumor tissues(Amsterdam [u.a.] : Elsevier, 2022) Gelbrich, Nadine; Miebach, Lea; Berner, Julia; Freund, Eric; Saadati, Fariba; Schmidt, Anke; Stope, Matthias; Zimmermann, Uwe; Burchardt, Martin; Bekeschus, SanderIntroduction: Medical gas plasma therapy has been successfully applied to several types of cancer in preclinical models. First palliative tumor patients suffering from advanced head and neck cancer benefited from this novel therapeutic modality. The gas plasma-induced biological effects of reactive oxygen and nitrogen species (ROS/RNS) generated in the plasma gas phase result in oxidation-induced lethal damage to tumor cells. Objectives: This study aimed to verify these anti-tumor effects of gas plasma exposure on urinary bladder cancer. Methods: 2D cell culture models, 3D tumor spheroids, 3D vascularized tumors grown on the chicken chorion-allantois-membrane (CAM) in ovo, and patient-derived primary cancer tissue gas plasma-treated ex vivo were used. Results: Gas plasma treatment led to oxidation, growth retardation, motility inhibition, and cell death in 2D and 3D tumor models. A marked decline in tumor growth was also observed in the tumors grown in ovo. In addition, results of gas plasma treatment on primary urothelial carcinoma tissues ex vivo highlighted the selective tumor-toxic effects as non-malignant tissue exposed to gas plasma was less affected. Whole-transcriptome gene expression analysis revealed downregulation of tumor-promoting fibroblast growth factor receptor 3 (FGFR3) accompanied by upregulation of apoptosis-inducing factor 2 (AIFm2), which plays a central role in caspase-independent cell death signaling. Conclusion: Gas plasma treatment induced cytotoxicity in patient-derived cancer tissue and slowed tumor growth in an organoid model of urinary bladder carcinoma, along with less severe effects in non-malignant tissues. Studies on the potential clinical benefits of this local and safe ROS therapy are awaited.
- ItemSize, concentration, and origin of human exhaled particles and their dependence on human factors with implications on infection transmission(Amsterdam [u.a.] : Elsevier, 2022) Bagheri, Gholamhossein; Schlenczek, Oliver; Turco, Laura; Thiede, Birte; Stieger, Katja; Kosub, Jana M.; Clauberg, Sigrid; Pöhlker, Mira L.; Pöhlker, Christopher; Moláček, Jan; Scheithauer, Simone; Bodenschatz, EberhardUnderstanding infection transmission between individuals, as well as evaluating the efficacy of protective measures, are key issues in pandemics driven by human respiratory particles. The key is a quantitative understanding of the size and concentration of particles exhaled and their variability across the size range for a representative population of all ages, genders, and different activities. Here we present data from 132 healthy volunteers aged 5 to 80 years, measured over the entire particle size range for each individual. Conventional particle spectrometry was combined with in-line holography under well-controlled conditions for common activities such as breathing, speaking, singing, and shouting. We find age to be the most important parameter for the concentration of small exhale particles <5 µm (PM5), which doubles over a 7-year period in adolescents and over a 30-year period in adults. Gender, body mass index, smoking or exercise habits have no discernible effect. We provide evidence that particles with a diameter of <5 µm originate from the lower respiratory tract, 5–15 µm from the larynx/pharynx, and >15 µm from the oral cavity. PM5 concentration can vary by one order of magnitude within a person, while inter-person variability can span two orders of magnitude, largely explained by difference in age. We found no discernible inter-person variability for particles larger than 5 µm. Our results show that cumulative volume of PM5 is 2–8 times higher in adults than in children. In contrast, number and volume concentration of larger particles, which are produced predominantly in the upper respiratory tract, is largely independent of age. Finally, we examined different types of airborne-transmissible respiratory diseases and provided insights into possible modes of infection transmission with and without several types/fits of face masks.