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    Dynamic formation of oriented patches in chondrocyte cell cultures
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2010) Grote, Marcus; Palumberi, Viviana; Wagner, Barbara; Barbero, Andrea; Martin, Ivan
    Growth factors have a significant impact not only on the growth dynamics but also on the phenotype of chondrocytes (Barbero et al. , J. Cell. Phys. 204, pp. 830-838, 2005). In particular, as chondrocyte populations approach confluence, the cells tend to align and form coherent patches. Starting from a mathematical model for fibroblast populations at equilibrium (Mogilner et al., Physica D 89, pp. 346-367, 1996), a dynamic continuum model with logistic growth is developed. Both linear stability analysis and numerical solutions of the time-dependent nonlinear integro-partial differential equation are used to identify the key parameters that lead to pattern formation in the model. The numerical results are compared quantitatively to experimental data by extracting statistical information on orientation, density and patch size through Gabor filters.
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    Adaptive smoothing of digital images : the R package adimpro
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2006) Polzehl, Jörg; Tabelow, Karsten
    Digital imaging has become omnipresent in the past years with a bulk of applications ranging from medical imaging to photography. When pushing the limits of resolution and sensitivity noise has ever been a major issue. However, commonly used non-adaptive filters can do noise reduction at the cost of a reduced effective spatial resolution only. Here we present a new package adimpro for R, which implements the Propagation-Separation approach by Polzehl and Spokoiny (2006) for smoothing digital images. This method naturally adapts to different structures of different size in the image and thus avoids oversmoothing edges and fine structures. We extend the method for imaging data with spatial correlation. Furthermore we show how the estimation of the dependence between variance and mean value can be included. We illustrate the use of the package through some examples.
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    Generating structured non-smooth priors and associated primal-dual methods
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2019) Hintermüller, Michael; Papafitsoros, Kostas
    The purpose of the present chapter is to bind together and extend some recent developments regarding data-driven non-smooth regularization techniques in image processing through the means of a bilevel minimization scheme. The scheme, considered in function space, takes advantage of a dualization framework and it is designed to produce spatially varying regularization parameters adapted to the data for well-known regularizers, e.g. Total Variation and Total Generalized variation, leading to automated (monolithic), image reconstruction workflows. An inclusion of the theory of bilevel optimization and the theoretical background of the dualization framework, as well as a brief review of the aforementioned regularizers and their parameterization, makes this chapter a self-contained one. Aspects of the numerical implementation of the scheme are discussed and numerical examples are provided.