2 results
Search Results
Now showing 1 - 2 of 2
- ItemNickel-catalysed carbonylative homologation of aryl iodides(London : Springer Nature, 2018) Peng, J.-B.; Wu, F.-P.; Qi, X.; Ying, J.; Wu, X.-F.Homologation is an important organic transformation which extends the carbon chain of a parent molecule, and many procedures have been established. However, although carbonylation reactions are now well developed as valuable methods for the synthesis of carbonyl-containing compounds, studies of carbonylative homologation are limited. Here we report a nickel-catalysed carbonylative homologation of aryl iodides. With molybdenum hexacarbonyl as the solid carbon monoxide source and silane as the deoxygenation reagent, benzylic units can be effectively produced. Various (hetero)arenes can be successfully benzylated and give the corresponding products in moderate to excellent yields.
- ItemCopper/iron co-catalyzed alkoxycarbonylation of unactivated alkyl bromides(London : Springer Nature, 2018) Li, Y.; Wu, X.-F.Carbonylative transformations of alkyl bromides have been explored less than those of aryl halides, in part because of the high barrier to activation of aryl bromides. Additionally, alkyl-metal reagents formed in situ can tend to undergo β-hydride elimination. Here we describe a copper/iron co-catalyzed alkoxycarbonylation of unactivated alkyl bromides. In the presence of catalytic quantities of iron and copper catalysts, primary, secondary, and tertiary alkyl bromides are carbonylatively transformed into the corresponding aliphatic esters in good yields. A potential reaction mechanism is proposed based on control experiments.