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DDC: 540 × Publisher: Cambridge : RSC × Subject: Amides × Subject: Ligands ×

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    Hydration of nitriles using a metal-ligand cooperative ruthenium pincer catalyst
    (Cambridge : RSC, 2019) Guo, Beibei; de Vries, Johannes G.; Otten, Edwin
    Nitrile hydration provides access to amides that are important structural elements in organic chemistry. Here we report catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyze the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in tBuOH as solvent. Reactions occur under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration is proposed that is initiated by metal-ligand cooperative binding of the nitrile. This journal is © The Royal Society of Chemistry.