Search Results

Now showing 1 - 4 of 4
  • Item
    Alterations in Event Related Potentials (ERP) associated with tinnitus distress and attention
    (Dordrecht [u.a.] : Springer Science + Business Media B.V, 2008) Delb, W.; Strauss, D.J.; Low, Y.F.; Seidler, H.; Rheinschmitt, A.; Wobrock, T.; D'Amelio, R.
    Tinnitus related distress corresponds to different degrees of attention paid to the tinnitus. Shifting attention to a signal other than the tinnitus is therefore particularly difficult for patients with high tinnitus related distress. As attention effects on Event Related Potentials (ERP) have been shown this should be reflected in ERP measurements (N100, phase locking). In order to prove this hypothesis single sweep ERP recordings were obtained in 41 tinnitus patients as well as 10 control subjects during a period of time when attention was shifted to a tone (attended) and during a second phase (unattended) when they did not focus attention to the tone. Whereas tinnitus patients with low distress showed a significant reduction in both N100 amplitude and phase locking when comparing the attended and unattended measurement condition a group of patients with high tinnitus related distress did not show such ERP alterations. Using single sweep ERP measurements the results of our study show, that attention in high tinnitus related distress patients is captured by their tinnitus significantly more than in low distress patients. Furthermore our results provide the basis for future neurofeedback based tinnitus therapies aiming at maximizing the ability to shift attention away from the tinnitus. © 2008 The Author(s).
  • Item
    Order patterns networks (orpan) - A method to estimate time-evolving functional connectivity from multivariate time series
    (Lausanne : Frontiers Research Foundation, 2012) Schinkel, S.; Zamora-López, G.; Dimigen, O.; Sommer, W.; Kurths, J.
    Complex networks provide an excellent framework for studying the function of the human brain activity. Yet estimating functional networks from measured signals is not trivial, especially if the data is non-stationary and noisy as it is often the case with physiological recordings. In this article we propose a method that uses the local rank structure of the data to define functional links in terms of identical rank structures. The method yields temporal sequences of networks which permits to trace the evolution of the functional connectivity during the time course of the observation. We demonstrate the potentials of this approach with model data as well as with experimental data from an electrophysiological study on language processing.
  • Item
    EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier
    (Gotenburg : Research Network of Computational and Structural Biotechnology (RNCSB), 2022) Semyachkina-Glushkovskaya, O.V.; Karavaev, A.S.; Prokhorov, M.D.; Runnova, A.E.; Borovkova, E.I.; Ishbulatov, Yu.M.; Hramkov, A.N.; Kulminskiy, D.D.; Semenova, N.I.; Sergeev, K.S.; Slepnev, A.V.; Sitnikova, E.Yu.; Zhuravlev, M.O.; Fedosov, I.V.; Shirokov, A.A.; Blokhina, I.A.; Dubrovski, A.I.; Terskov, A.V.; Khorovodov, A.P.; Ageev, V.B.; Elovenko, D.A.; Evsukova, A.S.; Adushkina, V.V.; Telnova, V.V.; Postnov, D.E.; Penzel, T.U.; Kurths, J.G.
    The lymphatic drainage system of the brain (LDSB) is the removal of metabolites and wastes from its tissues. A dysfunction of LDSB is an important sign of aging, brain oncology, the Alzheimer's and Parkinson's diseases. The development of new strategies for diagnosis of LDSB injuries can improve prevention of age-related cerebral amyloid angiopathy, neurodegenerative and cerebrovascular diseases. There are two conditions, such as deep sleep and opening of the blood-brain-barrier (OBBB) associated with the LDSB activation. A promising candidate for measurement of LDSB could be electroencephalography (EEG). In this pilot study on rats, we tested the hypothesis, whether deep sleep and OBBB can be an informative platform for an effective extracting of information about the LDSB functions. Using the nonlinear analysis of EEG dynamics and machine learning technology, we discovered that the LDSB activation during OBBB and sleep is associated with similar changes in the EEG θ-activity. The OBBB causes the higher LDSB activation vs. sleep that is accompanied by specific changes in the low frequency EEG activity extracted by the power spectra analysis of the EEG dynamics combined with the coherence function. Thus, our findings demonstrate a link between neural activity associated with the LDSB activation during sleep and OBBB that is an important informative platform for extraction of the EEG-biomarkers of the LDSB activity. These results open new perspectives for the development of technology for the LDSB diagnostics that would open a novel era in the prognosis of brain diseases caused by the LDSB disorders, including OBBB.
  • Item
    Frequency spectrum recurrence analysis
    ([London] : Macmillan Publishers Limited, part of Springer Nature, 2020) Ladeira, Guênia; Marwan, Norbert; Destro-Filho, João-Batista; Davi Ramos, Camila; Lima, Gabriela
    In this paper, we present the new frequency spectrum recurrence analysis technique by means of electro-encephalon signals (EES) analyses. The technique is suitable for time series analysis with noise and disturbances. EES were collected, and alpha waves of the occipital region were analysed by comparing the signals from participants in two states, eyes open and eyes closed. Firstly, EES were characterized and analysed by means of techniques already known to compare with the results of the innovative technique that we present here. We verified that, standard recurrence quantification analysis by means of EES time series cannot statistically distinguish the two states. However, the new frequency spectrum recurrence quantification exhibit quantitatively whether the participants have their eyes open or closed. In sequence, new quantifiers are created for analysing the recurrence concentration on frequency bands. These analyses show that EES with similar frequency spectrum have different recurrence levels revealing different behaviours of the nervous system. The technique can be used to deepen the study on depression, stress, concentration level and other neurological issues and also can be used in any complex system.