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    Physiological Parameters Relevant to Dissolution Testing - Hydrodynamic Considerations (rev. and suppl. version)
    (Tübingen : Universitätsbibliothek Tübingen, 2023) Diebold, Steffen M.
    The first two sections of the monograph present an introduction into basic hydrodynamics relevant to in vitro dissolution testing including V. G. Levichs convective diffusion theory and the authors combination model. This part is followed by hydrodynamic considerations of in vivo dissolution including hydrodynamic problems inherent to in vivo bioavailability of solid oral dosage forms. Hydrodynamics in the upper GI tract contribute to in vivo dissolution. Our ability to forecast dissolution of poorly soluble drugs in vitro depends on our knowledge of and ability to control hydrodynamics as well as other factors influencing dissolution. Provided suitable conditions (apparatus, hydrodynamics, media) are chosen for the dissolution test, it seems possible to predict dissolution limitations to the oral absorption of drugs and to reflect variations in hydrodynamic conditions in the upper GI tract. The fluid volume available for dissolution in the gut lumen, the contact time of the dissolved compound with the absorptive sites and the particle size have been identified as the main hydrodynamic determinants for the absorption of poorly soluble drugs in vivo. The influence of these factors is usually more pronounced than that of the motility pattern or the gastrointestinal flow rates per se.
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    Advanced Materials Safety 2023: Abstract book
    (Zenodo, 2023) Leibniz Research Alliance Advanced Materials Safety
    With this abstract book, the organizers of the conference Advanced Materials Safety 2023, publish the abstracts of the works that are presented during the conference. The functionality of advanced materials, their impact on humans and the environment as well as the acceptance of the technologies are the focus of the conference. With the Advanced Materials Safety 2023, we bring together researchers with different relevant expertise and identify possible interfaces for joint research projects that allow us to investigate such complex challenges.