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    ATMODAT Standard v3.0
    (Hamburg : DKRZ, 2020) Gasnke, Anette; Kraft, Angelina; Kaiser, Amandine; Heydebreck, Daniel; Lammert, Andrea; Höck, Heinke; Thiemann, Hannes; Voss, Vivien; Grawe, David; Leitl, Bernd; Schlünzen, K. Heinke; Kretzschmar, Jan; Quaas, Johannes
    Within the AtMoDat project (Atmospheric Model Data), a standard has been developed which is meant for improving the FAIRness of atmospheric model data published in repositories. The ATMODAT standard includes concrete recommendations related to the maturity, publication and enhanced FAIRness of atmospheric model data. The suggestions include requirements for rich metadata with controlled vocabularies, structured landing pages, file formats (netCDF) and the structure within files. Human- and machine readable landing pages are a core element of this standard, and should hold and present discipline-specific metadata on simulation and variable level. This standard is an updated and translated version of "Bericht über initialen Kernstandard und Kurationskriterien des AtMoDat Projektes (v2.4)
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    The First Report of mcr-1-Carrying Escherichia coli Originating from Animals in Serbia
    (Basel : MDPI, 2021) Mišić, Dušan; Kiskaroly, Ferenc; Szostak, Michael P.; Cabal, Adriana; Ruppitsch, Werner; Bernreiter-Hofer, Tanja; Milovanovic, Viktoria; Feßler, Andrea T.; Allerberger, Franz; Spergser, Joachim; Müller, Elke; Schwarz, Stefan; Braun, Sascha D.; Monecke, Stefan; Ehricht, Ralf; Korus, Maciej; Benković, Damir; Korzeniowska, Malgorzata; Loncaric, Igor
    The aim of this study was continuous monitoring of the presence of mcr-1 to mcr-5 genes in Enterobacterales isolated from cattle, pigs, and domestic poultry at intensive breeding facilities in Northern Vojvodina, Serbia, from 1 January 1 to 1 October 2020. Out of 2167 examined samples, mcr-1 was observed in five E. coli isolates originating from healthy turkeys. Four isolates belonged to the phylogenetic group B1, and one isolate to the phylogenetic group A. Detected E. coli serogenotypes (somatic O and flagellar H antigens) were O8:H25 and O29:H25. Core-genome multi-locus sequence typing (cgMLST) revealed three ST58 isolates clustering together in Clonal Complex (CC) 155 and two singletons of ST641-CC86 and ST410-CC23, respectively. Clonotyping revealed CH4-32 (n = 3), CH6-53 (n = 1) and CH4-24 (n = 1). In all isolates, the mcr-1 gene was located on a large IncX4 replicon type plasmid. Eight virulence-associated genes (VAGs) typical of avian pathogenic E. coli (APEC) (fyuA, fimH, hlyF, iss, ompT, sitA, traT, iroN) were detected in four isolates. These isolates were investigated for susceptibility to four biocides and revealed MIC values of 0.125% for glutardialdehyde, of 0.00003-0.00006% for chlorohexidine, of 4-6% for isopropanol and of 0.001-0.002% for benzalkonium chloride. All obtained MIC values of the tested biocides were comparable to the reference strain, with no indication of possible resistance. This is the first report of mcr-1.1-carrying E. coli from Serbia. Although only samples from turkeys were mcr-positive in this study, continuous monitoring of livestock samples is advised to prevent a spill-over from animals to humans.
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    The Berlin principles on one health - Bridging global health and conservation
    (Amsterdam [u.a.] : Elsevier Science, 2020) Gruetzmacher, Kim; Karesh, William B.; Amuasi, John H.; Arshad, Adnan; Farlow, Andrew; Gabrysch, Sabine; Jetzkowitz, Jens; Lieberman, Susan; Palmer, Clare; Winkler, Andrea S.; Walzer, Chris
    For over 15-years, proponents of the One Health approach have worked to consistently interweave components that should never have been separated and now more than ever need to be re-connected: the health of humans, non-human animals, and ecosystems. We have failed to heed the warning signs. A One Health approach is paramount in directing our future health in this acutely and irrevocably changed world. COVID-19 has shown us the exorbitant cost of inaction. The time to act is now. © 2020
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    Gelation kinetics of thiol-methylsulfone (MS) hydrogel formulations for 3D cell culture
    (Washington, D.C. : American Chemical Society, 2022) de Miguel-Jiménez, Adrián; Ebeling, Bastian; Paez, Julieta I.; Fink-Straube, Claudia; Pearson, Samuel; del Campo, Aranzazu
    Crosslinking chemistries that allow hydrogel formation within minutes are essential to achieve homogeneous networks and cell distributions in 3D cell culture. Thiol-methylsulfone (MS) crosslinking chemistry offers minutes-scale gelation under near-physiological conditions showing many desirable attributes for 3D cell encapsulation. Here we investigate the gelation kinetics and mechanical properties of PEG-based hydrogels formed by thiol-tetrazole methylsulfone (TzMS) crosslinking as a function of buffer, crosslinker structure, and degree of TzMS functionalization. Appropriate buffer selection ensured constant pH throughout crosslinking. The formulation containing cell adhesive ligand RGD and enzymatically-degradable peptide VPM gelled in ca. 4 min at pH 7.5, and stiffness could be increased from hundreds of Pascals to > 1 kPa by using excess VPM. The gelation times and stiffnesses for these hydrogels are highly suitable for 3D cell encapsulations, and pave the way for reliable 3D cell culture workflows in pipetting robots.
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    Limiting global warming to 1.5 °C will lower increases in inequalities of four hazard indicators of climate change
    (Bristol : IOP Publ., 2019) Shiogama, Hideo; Hasegawa, Tomoko; Fujimori, Shinichiro; Murakami, Daisuke; Takahashi, Kiyoshi; Tanaka, Katsumasa; Emori, Seita; Kubota, Izumi; Abe, Manabu; Imada, Yukiko; Watanabe, Masahiro; Mitchell, Daniel; Schaller, Nathalie; Sillmann, Jana; Fischer, Erich M.; Scinocca, John F.; Bethke, Ingo; Lierhammer, Ludwig; Takakura, Jun’ya; Trautmann, Tim; Döll, Petra; Ostberg, Sebastian; Müller Schmied, Hannes; Saeed, Fahad; Schleussner, Carl-Friedrich
    Clarifying characteristics of hazards and risks of climate change at 2 °C and 1.5 °C global warming is important for understanding the implications of the Paris Agreement. We perform and analyze large ensembles of 2 °C and 1.5 °C warming simulations. In the 2 °C runs, we find substantial increases in extreme hot days, heavy rainfalls, high streamflow and labor capacity reduction related to heat stress. For example, about half of the world's population is projected to experience a present day 1-in-10 year hot day event every other year at 2 °C warming. The regions with relatively large increases of these four hazard indicators coincide with countries characterized by small CO2 emissions, low-income and high vulnerability. Limiting global warming to 1.5 °C, compared to 2 °C, is projected to lower increases in the four hazard indicators especially in those regions.
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    Cascading Hazards in the Aftermath of Australia's 2019/2020 Black Summer Wildfires
    (Hoboken, NJ : Wiley-Blackwell, 2021) Kemter, M.; Fischer, M.; Luna, L.V.; Schönfeldt, E.; Vogel, J.; Banerjee, A.; Korup, O.; Thonicke, K.
    Following an unprecedented drought, Australia's 2019/2020 “Black Summer” fire season caused severe damage, gravely impacting both humans and ecosystems, and increasing susceptibility to other hazards. Heavy precipitation in early 2020 led to flooding and runoff that entrained ash and soil in burned areas, increasing sediment concentration in rivers, and reducing water quality. We exemplify this hazard cascade in a catchment in New South Wales by mapping burn severity, flood, and rainfall recurrence; estimating changes in soil erosion; and comparing them with river turbidity data. We show that following the extreme drought and wildfires, even moderate rain and floods led to undue increases in soil erosion and reductions in water quality. While natural risk analysis and planning commonly focuses on a single hazard, we emphasize the need to consider the entire hazard cascade, and highlight the impacts of ongoing climate change beyond its direct effect on wildfires.
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    Metadatenschema für Schulungsmaterialien zum Thema Forschungsdatenmanagement
    (Meyrin : CERN, 2020-04-27) Biernacka, Katarzyna; Danker, Sarah Ann; Engelhardt, Claudia; Helbig, Kerstin; Hendriks, Sonja; Jacob, Juliane; Jagusch, Gerald; Lanza, Giacomo; Leone, Claudio; Meier, Kristin; Neumann, Janna; Odebrecht, Carolin; Peters, Karsten; Rehwald, Stephanie; Rex, Jessica; Senft, Matthias; Strauch, Annette; Thiemann, Kathrin; Trautwein-Bruns, Ute; Wiljes, Cord; Wuttke, Ulrike; Ziedorn, Frauke
    Das Dokument enthält ein Metadatenschema für Schulungsmaterialien zum Thema Forschungsdatenmanagement. Dieses Schema wurde von der UAG Schulungen/Fortbildungen der DINI/nestor AG Forschungsdaten erstellt und bei der Materialsammlung von FDM-Schulungsmaterialien unter umgesetzt.
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    Cascade Synthesis of Pyrroles from Nitroarenes with Benign Reductants Using a Heterogeneous Cobalt Catalyst
    (Weinheim : Wiley-VCH, 2020) Ryabchuk, Pavel; Leischner, Thomas; Kreyenschulte, Carsten; Spannenberg, Anke; Junge, Kathrin; Beller, Matthias
    A bifunctional 3d-metal catalyst for the cascade synthesis of diverse pyrroles from nitroarenes is presented. The optimal catalytic system Co/NGr-C@SiO2-L is obtained by pyrolysis of a cobalt-impregnated composite followed by subsequent selective leaching. In the presence of this material, (transfer) hydrogenation of easily available nitroarenes and subsequent Paal–Knorr/Clauson-Kass condensation provides >40 pyrroles in good to high yields using dihydrogen, formic acid, or a CO/H2O mixture (WGSR conditions) as reductant. In addition to the favorable step economy, this straightforward domino process does not require any solvents or external co-catalysts. The general synthetic utility of this methodology was demonstrated on a variety of functionalized substrates including the preparation of biologically active and pharmaceutically relevant compounds, for example, (+)-Isamoltane. © 2020 The Authors. Published by Wiley-VCH GmbH
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    Quantifying the parameter dependent basin of the unsafe regime of asymmetric Lévy-noise-induced critical transitions
    (Dordrecht [u.a.] : Springer, 2021) Ma, Jinzhong; Xu, Yong; Li, Yongge; Tian, Ruilan; Ma, Shaojuan; Kurths, J.
    In real systems, the unpredictable jump changes of the random environment can induce the critical transitions (CTs) between two non-adjacent states, which are more catastrophic. Taking an asymmetric Lévy-noise-induced tri-stable model with desirable, sub-desirable, and undesirable states as a prototype class of real systems, a prediction of the noise-induced CTs from the desirable state directly to the undesirable one is carried out. We first calculate the region that the current state of the given model is absorbed into the undesirable state based on the escape probability, which is named as the absorbed region. Then, a new concept of the parameter dependent basin of the unsafe regime (PDBUR) under the asymmetric Lévy noise is introduced. It is an efficient tool for approximately quantifying the ranges of the parameters, where the noise-induced CTs from the desirable state directly to the undesirable one may occur. More importantly, it may provide theoretical guidance for us to adopt some measures to avert a noise-induced catastrophic CT. © 2021, The Author(s).
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    Train-the-Trainer Konzept zum Thema Forschungsdatenmanagement - Version 3.1
    (Meyrin : CERN, 2020-12-18) Biernacka, Katarzyna; Buchholz, Petra; Danker, Sarah Ann; Dolzycka, Dominika; Engelhardt, Claudia; Helbig, Kerstin; Jacob, Juliane; Neumann, Janna; Odebrecht, Carolin; Wiljes, Cord; Wuttke, Ulrike
    Im Rahmen des BMBF-Projekts FDMentor wurde ein deutschsprachiges Train-the-Trainer Programm zum Thema Forschungsdatenmanagement (FDM) erstellt, das nach Projektende durch Mitglieder der UAG Schulungen/Fortbildungen der DINI/nestor-AG Forschungsdaten ergänzt und aktualisiert wurde. Die behandelten Themen umfassen sowohl die Aspekte des Forschungsdatenmanagements als auch didaktische Einheiten zu Lernkonzepten, Workshopgestaltung und eine Reihe von didaktischen Methoden. Die nun veröffentlichte dritte, überarbeitete und erweiterte Version des Train-the-Trainer-Konzepts enthält Einheiten zu Methoden und Materialien für Online-Veranstaltungen. Erste Erfahrungen aus bereits online durchgeführten Train-the-Trainer-Workshops sind zusätzlich in das Konzept eingeflossen. Die mit dieser Version eingeführten didaktischen Methoden für Online-Veranstaltungen sollen die geschulten Trainer*innen dabei unterstützen, ihre Schulungsangebote auch im virtuellen Raum lebendig und interaktiv zu gestalten und dient somit auch der weitergehenden Information der bereits geschulten Teilnehmer*innen. An English version of the "Train-the-Trainer Konzept zum Forschungsdatenmanagement" is available under