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Version: publishedVersion × Subject: Evolution ×

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Now showing 1 - 4 of 4
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    OGHReS: Large-scale filaments in the outer Galaxy
    (Les Ulis : EDP Sciences, 2021) Colombo, D.; König, C.; Urquhart, J. S.; Wyrowski, F.; Mattern, M.; Menten, K. M.; Lee, M.-Y.; Brand, J.; Wienen, M.; Mazumdar, P.; Schuller, F.; Leurini, S.
    Filaments are a ubiquitous morphological feature of the molecular interstellar medium and are identified as sites of star formation. In recent years, more than 100 large-scale filaments (with a length > 10 pc) have been observed in the inner Milky Way. As they appear linked to Galactic dynamics, studying those structures represents an opportunity to link kiloparsec-scale phenomena to the physics of star formation, which operates on much smaller scales. In this Letter, we use newly acquired Outer Galaxy High Resolution Survey (OGHReS) 12CO(2-1) data to demonstrate that a significant number of large-scale filaments are present in the outer Galaxy as well. The 37 filaments identified appear tightly associated with inter-arm regions. In addition, their masses and linear masses are, on average, one order of magnitude lower than similar-sized molecular filaments located in the inner Galaxy, showing that Milky Way dynamics is able to create very elongated features in spite of the lower gas supply in the Galactic outskirts.
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    Editorial: New insights and updates on the molecular epidemiology and antimicrobial resistance of MRSA in humans in the whole-genome sequencing era
    (Lausanne : Frontiers Media, 2019) Coleman, David C.; Shore, Anna C.; Goering, Richard V.; Monecke, Stefan
    [No abstract available]
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    Biodiversity research: Data without theory-theory without data
    (Lausanne : Frontiers Media, 2015) Rillig, Matthias C.; Kiessling, Wolfgang; Borsch, Thomas; Gessler, Arthur; Greenwood, Alex D.; Hofer, Heribert; Joshi, Jasmin; Schröder, Boris; Thonicke, Kirsten; Tockner, Klement; Weisshuhn, Karoline; Jeltsch, Florian
    [No abstract available]
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    Exploring the evolution and epidemiology of European CC1-MRSA-IV: tracking a multidrug-resistant community-associated meticillin-resistant Staphylococcus aureus clone
    (London : Soc., 2021) Earls, Megan R.; Steinig, Eike J.; Monecke, Stefan; Samaniego Castruita, José A.; Simbeck, Alexandra; Schneider-Brachert, Wulf; Vremerǎ, Teodora; Dorneanu, Olivia S.; Loncaric, Igor; Bes, Michèle; Lacoma, Alicia; Prat Aymerich, Cristina; Wernery, Ulrich; Armengol-Porta, Marc; Blomfeldt, Anita; Duchene, Sebastian; Bartels, Mette D.; Ehricht, Ralf; Coleman, David C.
    This study investigated the evolution and epidemiology of the community-associated and multidrug-resistant Staphylococcus aureus clone European CC1-MRSA-IV. Whole-genome sequences were obtained for 194 European CC1-MRSA-IV isolates (189 of human and 5 of animal origin) from 12 countries, and 10 meticillin-susceptible precursors (from North-Eastern Romania; all of human origin) of the clone. Phylogenetic analysis was performed using a maximum-likelihood approach, a time-measured phylogeny was reconstructed using Bayesian analysis, and in silico microarray genotyping was performed to identify resistance, virulence-associated and SCCmec (staphylococcal cassette chromosome mec) genes. Isolates were typically sequence type 1 (190/204) and spa type t127 (183/204). Bayesian analysis indicated that European CC1-MRSA-IV emerged in approximately 1995 before undergoing rapid expansion in the late 1990s and 2000s, while spreading throughout Europe and into the Middle East. Phylogenetic analysis revealed an unstructured meticillin-resistant S. aureus (MRSA) population, lacking significant geographical or temporal clusters. The MRSA were genotypically multidrug-resistant, consistently encoded seh, and intermittently (34/194) encoded an undisrupted hlb gene with concomitant absence of the lysogenic phage-encoded genes sak and scn. All MRSA also harboured a characteristic ~5350 nt insertion in SCCmec adjacent to orfX. Detailed demographic data from Denmark showed that there, the clone is typically (25/35) found in the community, and often (10/35) among individuals with links to South-Eastern Europe. This study elucidated the evolution and epidemiology of European CC1-MRSA-IV, which emerged from a meticillin-susceptible lineage prevalent in North-Eastern Romania before disseminating rapidly throughout Europe.