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    Open Access im Blick! Mehr Sichtbarkeit von Open-Access-Publikationen in der Bibliothek – Projekt visOA
    (Berlin : De Gruyter, 2020) Geith, Uwe; Kraß, Thomas
    In order to bring Open Access publications more into the perception of library users, it is necessary to make them more visible. In the visOA project, carried out by the NTNM library of the INM, Open Access publications were clearly highlighted in the OPAC as well as in the Discovery System and in the publication lists of the INM. A self-programmed virtual journal display (VIDIJO) also offers a subject-specific selection of Open Access journals. The effectiveness of the measures taken in the project was verified by accompanying research.
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    Possibilities and Limitations of Photoactivatable Cytochalasin D for the Spatiotemporal Regulation of Actin Dynamics
    (Washington, D.C. : American Chemical Society, 2020) Nair, Roshna V.; Zhao, Shifang; Terriac, Emmanuel; Lautenschläger, Franziska; Hetmanski, Joseph H.R.; Caswell, Patrick T.; del Campo, Aranzazu
    The study of the actin cytoskeleton and related cellular processes requires tools to specifically interfere with actin dynamics in living cell cultures, ideally with spatiotemporal control and compatible with real time imaging. A phototriggerable derivative of the actin disruptor Cytochalasin D (CytoD) is described and tested here. It includes a nitroveratryloxycarbonyl (Nvoc) photoremovable protecting group (PPG) at the hydroxyl group at C7 of CytoD. The attachment of the PPG renders Nvoc-CytoD temporarily inactive, and enables light-dosed delivery of the active drug CytoD to living cells. This article presents the full structural and physicochemical characterization, the toxicity analysis. It is complemented with biological tests to show the time scales (seconds) and spatial resolution (cellular level) achievable with a UV source in a regular microscopy setup