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- ItemProspects and challenges of translational corneal bioprinting(Basel : MDPI AG, 2020) Fuest, Matthias; Yam, Gary Hin-Fai; Mehta, Jodhbir S.; Campos, Daniela F.DuarteCorneal transplantation remains the ultimate treatment option for advanced stromal and endothelial disorders. Corneal tissue engineering has gained increasing interest in recent years, as it can bypass many complications of conventional corneal transplantation. The human cornea is an ideal organ for tissue engineering, as it is avascular and immune-privileged. Mimicking the complex mechanical properties, the surface curvature, and stromal cytoarchitecure of the in vivo corneal tissue remains a great challenge for tissue engineering approaches. For this reason, automated biofabrication strategies, such as bioprinting, may offer additional spatial control during the manufacturing process to generate full-thickness cell-laden 3D corneal constructs. In this review, we discuss recent advances in bioprinting and biomaterials used for in vitro and ex vivo corneal tissue engineering, corneal cell-biomaterial interactions after bioprinting, and future directions of corneal bioprinting aiming at engineering a full-thickness human cornea in the lab. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- ItemAn Empirical Study on 3D Artefacts in the Scientific Life Cycle(Hannover : Technische Informationsbibliothek, 2018) Struß, J.M.3D models, objects and data are being used in an increasing number of scientific disciplines throughout different points in the research life cycle. In addition to architecture, civil engineering and mechanical engineering – disciplines that traditionally plan and construct in three-dimensional space – they are also used in the fields of electrical engineering and information technology, physics and astronomy as well as in the conservation of cultural heritage. The types of models used differ considerably in the different disciplines. In addition to CAD models, there are for example formats such as point clouds resulting from laser scans, which are used to capture buildings or landscapes. In addition, there are simulations in which the temporal dimension also plays a role. Furthermore printable 3D models that allow the direct generation of a physical object are increasingly being created. The study presented here takes a closer look at the diversity of 3D artefacts, the point of their creation in the research lifecycle as well as the purpose these artefacts serve.
- ItemTetGen : a 3D Delaunay tetrahedral mesh generator version 1.2 user's manual(Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2002) Si, HangThis technical report describes the main features and the using of TetGen, a 3D Delaunay tetrahedral mesh generator. Based on the most recent developments in mesh generation algorithms, this program has been specifically designed to fulfill the task of automatically generating high quality tetrahedral meshes, which are suitable for scientific computing using numerical methods such as finite element and finite volume methods. In this document, the user will learn how to create 3D tetrahedral meshes using TetGen's input files and command line switches. Various examples were given for better understanding. This document describes the features of the version 1.2.