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Subject: High yield ×

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    A general strategy for the synthesis of α-trifluoromethyl- and α-perfluoroalkyl-β-lactams via palladium-catalyzed carbonylation
    (Cambridge : RSC, 2021) Li, Yang; Zhang, Cai-Lin; Huang, Wei-Heng; Sun, Ning; Hao, Meng; Neumann, Helfried; Beller, Matthias
    β-Lactam compounds play a key role in medicinal chemistry, specifically as the most important class of antibiotics. Here, we report a novel one-step approach for the synthesis of α-(trifluoromethyl)-β-lactams and related products from fluorinated olefins, anilines and CO. Utilization of an advanced palladium catalyst system with the Ruphos ligand allows for selective cycloaminocarbonylations to give diverse fluorinated β-lactams in high yields. © The Royal Society of Chemistry 2021.
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    Iron/N-doped graphene nano-structured catalysts for general cyclopropanation of olefins
    (Cambridge : RSC, 2020) Sarkar, Abhijnan; Formenti, Dario; Ferretti, Francesco; Kreyenschulte, Carsten; Bartling, Stephan; Junge, Kathrin; Beller, Matthias; Ragaini, Fabio
    The first examples of heterogeneous Fe-catalysed cyclopropanation reactions are presented. Pyrolysis of in situ-generated iron/phenanthroline complexes in the presence of a carbonaceous material leads to specific supported nanosized iron particles, which are effective catalysts for carbene transfer reactions. Using olefins as substrates, cyclopropanes are obtained in high yields and moderate diastereoselectivities. The developed protocol is scalable and the activity of the recycled catalyst after deactivation can be effectively restored using an oxidative reactivation protocol under mild conditions. This journal is © The Royal Society of Chemistry.