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- ItemMagnetic Micromotors for Multiple Motile Sperm Cells Capture, Transport, and Enzymatic Release(Weinheim : Wiley-VCH Verlag, 2020) Xu, H.; Medina-Sánchez, M.; Schmidt, O.G.An integrated system combining a magnetically-driven micromotor and a synthetized protein-based hyaluronic acid (HA) microflake is presented for the in situ selection and transport of multiple motile sperm cells (ca. 50). The system appeals for targeted sperm delivery in the reproductive system to assist fertilization or to deliver drugs. The binding mechanism between the HA microflake and sperm relies on the interactions between HA and the corresponding sperm HA receptors. Once sperm are captured within the HA microflake, the assembly is trapped and transported by a magnetically-driven helical microcarrier. The trapping of the sperm-microflake occurs by a local vortex induced by the microcarrier during rotation-translation under a rotating magnetic field. After transport, the microflake is enzymatically hydrolyzed by local proteases, allowing sperm to escape and finally reach the target location. This cargo-delivery system represents a new concept to transport not only multiple motile sperm but also other actively moving biological cargoes.
- ItemIdentification of representative dairy cattle and fodder crop production typologies at regional scale in Europe(Berlin ; Heidelberg : Springer, 2022) Díaz de Otálora, Xabier; Dragoni, Federico; Del Prado, Agustín; Estellés, Fernándo; Wilfart, Aurélie; Krol, Dominika; Balaine, Lorraine; Anestis, Vasileios; Amon, BarbaraEuropean dairy production faces significant economic, environmental, and social sustainability challenges. Given the great diversity of dairy cattle production systems in Europe, region-specific concepts to improve environmental and socioeconomic sustainability are needed. Regionally integrated dairy cattle-crop systems emerge as a more resilient and sustainable alternative to highly specialized farming systems. Identifying different dairy cattle production typologies and their potential interactions with fodder crop production is presented as a step in transitioning to optimized agricultural systems. Currently existing typologies of integrated systems are often insufficient when characterizing structural, socioeconomic, and environmental components of farms. We fill this gap in the literature by identifying, describing, and comparing representative dairy cattle production system typologies and their interrelation with regional fodder crop production at the European regional scale. This is a necessary step to assess the scope for adapted mitigation and sustainability measures in the future. For this purpose, a multivariate statistical approach is applied. We show how different land-use practices, farm structure characteristics, socio-economic attributes, and emission intensities condition dairy production. Furthermore, the diversity of regional fodder crop production systems is demonstrated by analyzing their distribution in Europe. Together with identified typologies, varying degrees of regional specialization in milk production allow for identifying future strategies associated with the application of integrated systems in key European dairy regions. This study contributes to a better understanding of the existing milk production diversity in Europe and their relationship with regional fodder crop production. In addition, we discuss the benefits of integrated systems as a clear, viable, and resilient alternative to ongoing livestock intensification in the European context. Identifying interactions between components of integrated systems will facilitate decision-making, the design and implementation of measures to mitigate climate change, and the promotion of positive socio-economic and environmental interactions.