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Reconstruction of quasi-local numerical effective models from low-resolution measurements

2019, Caiazzo, Alfonso, Maier, Roland, Peterseim, Daniel

We consider the inverse problem of reconstructing an effective model for a prototypical diffusion process in strongly heterogeneous media based on low-resolution measurements. We rely on recent quasi-local numerical effective models that, in contrast to conventional homogenized models, are provably reliable beyond periodicity assumptions and scale separation. The goal of this work is to show that the identification of the matrix representation of these effective models is possible. Algorithmic aspects of the inversion procedure and its performance are illustrated in a series of numerical experiments.

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Identification of the thermal growth characteristics of coagulated tumor tissue in laser-induced thermotherapy

2011, Hömberg, Dietmar, Liu, Jujun, Togobytska, Nataliya

We consider an inverse problem arising in laser-induced thermotherapy, a minimally invasive method for cancer treatment, in which cancer tissues is destroyed by coagulation. For the dosage planning numerical simulation play an important role. To this end a crucial problem is to identify the thermal growth kinetics of the coagulated zone. Mathematically, this problem is a nonlinear and nonlocal parabolic heat source inverse problem. The solution to this inverse problem is defined as the minimizer of a nonconvex cost functional. The existence of the minimizer is proven. We derive the Gateaux derivative of the cost functional, which is based on the adjoint system, and use it for a numerical approximation of the optimal coefficient.