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Subject: Irradiation × WGL Institute: IPHT ×

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    Mitochondria Targeted Protein-Ruthenium Photosensitizer for Efficient Photodynamic Applications
    (Washington, DC : ACS Publications, 2017) Chakrabortty, Sabyasachi; Agrawalla, Bikram Keshari; Stumper, Anne; Vegi, Naidu M.; Fischer, Stephan; Reichardt, Christian; Kögler, Michael; Dietzek, Benjamin; Feuring-Buske, Michaela; Buske, Christian; Rau, Sven; Weil, Tanja
    Organelle-targeted photosensitization represents a promising approach in photodynamic therapy where the design of the active photosensitizer (PS) is very crucial. In this work, we developed a macromolecular PS with multiple copies of mitochondria-targeting groups and ruthenium complexes that displays highest phototoxicity toward several cancerous cell lines. In particular, enhanced anticancer activity was demonstrated in acute myeloid leukemia cell lines, where significant impairment of proliferation and clonogenicity occurs. Finally, attractive two-photon absorbing properties further underlined the great significance of this PS for mitochondria targeted PDT applications in deep tissue cancer therapy.
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    An electron beam profile instrument based on FBGs
    (Basel : MDPI AG, 2014) Sporea, D.; Stǎncǎlie, A.; Becherescu, N.; Becker, M.; Rothhardt, M.
    Along with the dose rate and the total irradiation dose measurements, the knowledge of the beam localization and the beam profile/energy distribution in the beam are parameters of interest for charged particle accelerator installations when they are used in scientific investigations, industrial applications or medical treatments. The transverse profile of the beam, its position, its centroid location, and its focus or flatness depend on the instrument operating conditions or on the beam exit setup. Proof-of-concept of a new type of charged particle beam diagnostics based on fiber Bragg gratings (FBGs) was demonstrated. Its operating principle relies on the measurement of the peak wavelength changes for an array of FBG sensors as function of the temperature following the exposure to an electron beam. Periodically, the sensor irradiation is stopped and the FBG are force cooled to a reference temperature with which the temperature influencing each sensor during beam exposure is compared. Commercially available FBGs, and FBGs written in radiation resistant optical fibers, were tested under electron beam irradiation in order to study their possible use in this application.