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Subject: Nanostructured materials × WGL Institute: IPF ×

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Now showing 1 - 2 of 2
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    Supramolecular assemblies of block copolymers as templates for fabrication of nanomaterials
    (New York, NY [u.a.] : Elsevier, 2011) Nandan, B.; Kuila, B.K.; Stamm, M.
    Self-assembled polymeric systems have played an important role as templates for nanofabrication; they offer nanotemplates with different morphologies and tunable sizes, are easily removed after reactions, and could be further modified with different functional groups to enhance the interactions. Among the various self-assembled polymeric systems, block copolymer supramolecular assemblies have received considerable attention because of the inherent processing advantages. These supramolecular assemblies are formed by the non-covalent interactions of one of the blocks of the block copolymer with a low molar-mass additive. Selective extraction of the additive leads to porous membranes or nano-objects which could then be used as templates for nanofabrication leading to a variety of ordered organic/inorganic nanostructures. In this feature article, we present an over-view of the recent developments in this area with a special focus on some examples from our group.
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    A thrombin-triggered self-regulating anticoagulant strategy combined with anti-inflammatory capacity for blood-contacting implants
    (Washington, DC [u.a.] : Assoc., 2022) Wang, Yanan; Wu, Haoshuang; Zhou, Zhongyi; Maitz, Manfred F.; Liu, Kunpeng; Zhang, Bo; Yang, Li; Luo, Rifang; Wang, Yunbing
    Interrelated coagulation and inflammation are impediments to endothelialization, a prerequisite for the longterm function of cardiovascular materials. Here, we proposed a self-regulating anticoagulant coating strategy combined with anti-inflammatory capacity, which consisted of thrombin-responsive nanogels with anticoagulant and anti-inflammatory components. As an anticoagulant, rivaroxaban was encapsulated in nanogels cross-linked by thrombin-cleavable peptide and released upon the trigger of environmental thrombin, blocking the further coagulation cascade. The superoxide dismutase mimetic Tempol imparted the antioxidant property. Polyphenol epigallocatechin gallate (EGCG), in addition to its anti-inflammatory function in synergy with Tempol, also acted as a weak cross-linker to stabilize the coating. The effectiveness and versatility of this coating were validated using two typical cardiovascular devices as models, biological valves and vascular stents. It was demonstrated that the coating worked as a precise strategy to resist coagulation and inflammation, escorted reendothelialization on the cardiovascular devices, and provided a new perspective for designing endothelium-like functional coatings.