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Subject: Polymersomes ×

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    The chemistry of cross-linked polymeric vesicles and their functionalization towards biocatalytic nanoreactors
    (Berlin ; Heidelberg : Springer, 2020) Moreno, Silvia; Voit, Brigitte; Gaitzsch, Jens
    Self-assembly of amphiphilic block copolymers into polymersomes continues to be a hot topic in modern research on biomimetics. Their well-known and valued mechanical strength can be increased even further if they are cross-linked. These additional bonds prevent a collapse or disassembly of the polymersomes and open the way towards smart nanoreactors. A variety of chemistries have been applied to obtain the desired cross-linked polymersomes, and therefore, the chemical approaches performed over time will be highlighted in this mini-review. Due to the large number of studies, a selected set of photo-cross-linked and pH-sensitive polymersomes will be specifically highlighted. This system has proven to be a very potent candidate for the formation of nanoreactors and drug delivery systems, and even for the formation of functional multicompartment cell mimics. [Figure not available: see fulltext.]. © 2020, The Author(s).
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    Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process
    (London : RSC Publishing, 2018) Ccorahua, Robert; Moreno, Silvia; Gumz, Hannes; Sahre, Karin; Voit, Brigitte; Appelhans, Dietmar
    Reconstitution of biologically active polymersomes from the frozen or solid state into any fluid state is still a challenging issue for the design of new biological experiments and for the formulation of therapeutic agents. To gain knowledge about the reconstitution of pH-responsive and photo-crosslinked polymersomes, surface-functionalized and enzyme-containing polymersomers were cryogenically frozen (-20 °C) or freeze-dried with inulin as the lyoprotectant (0.1% w/v) and stored for a defined time period. Reconstituting those polymersomes in solution by thawing or a re-dispersing process revealed their original physical properties as well as their function as a pH-switchable enzymatic nanoreactor.