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    A distributed control problem for a fractional tumor growth model
    (Basel : MDPI, 2019) Colli, Pierluigi; Gilardi, Gianni; Sprekels, Jürgen
    In this paper, we study the distributed optimal control of a system of three evolutionary equations involving fractional powers of three self-adjoint, monotone, unbounded linear operators having compact resolvents. The system is a generalization of a Cahn-Hilliard type phase field system modeling tumor growth that has been proposed by Hawkins-Daarud, van der Zee and Oden. The aim of the control process, which could be realized by either administering a drug or monitoring the nutrition, is to keep the tumor cell fraction under control while avoiding possible harm for the patient. In contrast to previous studies, in which the occurring unbounded operators governing the diffusional regimes were all given by the Laplacian with zero Neumann boundary conditions, the operators may in our case be different; more generally, we consider systems with fractional powers of the type that were studied in a recent work by the present authors. In our analysis, we show the Fréchet differentiability of the associated control-to-state operator, establish the existence of solutions to the associated adjoint system, and derive the first-order necessary conditions of optimality for a cost functional of tracking type. © 2019 by the authors.
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    Essential boundedness for solutions of the Neumann problem on general domains
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2019) ter Elst, A.F.M.; Meinlschmidt, Hannes; Rehberg, Joachim
    Let the domain under consideration be bounded. Under the suppositions of very weak Sobolev embeddings we prove that the solutions of the Neumann problem for an elliptic, second order divergence operator are essentially bounded, if the right hand sides are taken from the dual of a Sobolev space which is adapted to the above embedding.
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    Regularity of elastic fields in composites
    (Berlin : Weierstraß-Institut für Angewandte Analysis und Stochastik, 2006) Knees, Dorothee; Sändig, Anna-Margarete
    It is well known that high stress concentrations can occur in elastic composites in particular due to the interaction of geometrical singularities like corners, edges and cracks and structural singularities like jumping material parameters. In the project C5 "Stress concentrations in heterogeneous materials" of the SFB 404 "Multifield Problems in Solid and Fluid Mechanics" it was mathematically analyzed where and which kind of stress singularities in coupled linear and nonlinear elastic structures occur. In the linear case asymptotic expansions near the geometrical and structural peculiarities are derived, formulae for generalized stress intensity factors included. In the nonlinear case such expansions are unknown in general and regularity results are proved for elastic materials with power-law constitutive equations with the help of the difference quotient technique combined with a quasi-monotone covering condition for the subdomains and the energy densities. Furthermore, some applications of the regularity results to shape and structure optimization and the Griffith fracture criterion in linear and nonlinear elastic structures are discussed. Numerical examples illustrate the results.