Filters

2010 - 20163

More filters

2020 - 20223
Reset filters

Settings

Subject: glass fiber ×

Search Results

Now showing 1 - 3 of 3
  • Thumbnail Image
    Item
    Fiber enhanced Raman spectroscopic analysis as a novel method for diagnosis and monitoring of diseases related to hyperbilirubinemia and hyperbiliverdinemia
    (Cambridge : Soc., 2016) Yan, Di; Domes, Christian; Domes, Robert; Frosch, Timea; Popp, Jürgen; Pletz, Mathias W.; Frosch, Torsten
    Fiber enhanced resonance Raman spectroscopy (FERS) is introduced for chemically selective and ultrasensitive analysis of the biomolecules hematin, hemoglobin, biliverdin, and bilirubin. The abilities for analyzing whole intact, oxygenated erythrocytes are proven, demonstrating the potential for the diagnosis of red blood cell related diseases, such as different types of anemia and hemolytic disorders. The optical fiber enables an efficient light-guiding within a miniaturized sample volume of only a few micro-liters and provides a tremendously improved analytical sensitivity (LODs of 0.5 μM for bilirubin and 0.13 μM for biliverdin with proposed improvements down to the pico-molar range). FERS is a less invasive method than the standard ones and could be a new analytical method for monitoring neonatal jaundice, allowing a precise control of the unconjugated serum bilirubin levels, and therefore, providing a better prognosis for newborns. The potential for sensing very low concentrations of the bile pigments may also open up new opportunities for cancer research. The abilities of FERS as a diagnostic tool are explored for the elucidation of jaundice with different etiologies including the rare, not yet well understood diseases manifested in green jaundice. This is demonstrated by quantifying clinically relevant concentrations of bilirubin and biliverdin simultaneously in the micro-molar range: for the case of hyperbilirubinemia due to malignancy, infectious hepatitis, cirrhosis or stenosis of the common bile duct (1 μM biliverdin together with 50 μM bilirubin) and for hyperbiliverdinemia (25 μM biliverdin and 75 μM bilirubin). FERS has high potential as an ultrasensitive analytical technique for a wide range of biomolecules and in various life-science applications.
  • Thumbnail Image
    Item
    Microstructured optical fiber sensors embedded in a laminate composite for smart material applications
    (Basel : MDPI AG, 2011) Sonnenfeld, C.; Sulejmani, S.; Geernaert, T.; Eve, S.; Lammens, N.; Luyckx, G.; Voet, E.; Degrieck, J.; Urbanczyk, W.; Mergo, P.; Becker, M.; Bartelt, H.; Berghmans, F.; Thienpont, H.
    Fiber Bragg gratings written in highly birefringent microstructured optical fiber with a dedicated design are embedded in a composite fiber-reinforced polymer. The Bragg peak wavelength shifts are measured under controlled axial and transversal strain and during thermal cycling of the composite sample. We obtain a sensitivity to transversal strain that exceeds values reported earlier in literature by one order of magnitude. Our results evidence the relevance of using microstructured optical fibers for structural integrity monitoring of composite material structures.
  • Thumbnail Image
    Item
    Volume fraction determination of binary liquid mixtures by measurement of the equalization wavelength
    (Basel : MDPI, 2010) Martincek, I.; Pudis, D.; Kacik, D.; Schuster, K.
    A method for determination of the volume fraction in binary liquid mixtures by measurement of the equalization wavelength of intermodal interference of modes LP01 and LP11 in a liquid core optical fiber is presented in this paper. This method was studied using a liquid core optical fiber with fused silica cladding and a core made up of a binary silicon oil/chloroform liquid mixture with different volume fractions of chloroform. The interference technique used allows us to determine the chloroform volume fraction in the binary mixture with accuracy better than 0.1%. One of the most attractive advantages of presented method is very small volume of investigated mixture needed, as only a few hundred picoliters are necessary for reliable results. © 2010 by the authors.