2006, Stoll, N., Allwardt, A., Dingerdissen, U., Thurow, K.

Increasing economic globalization and mounting time and cost pressure on the development of new raw materials for the chemical industry as well as materials and environmental engineering constantly raise the demands on technologies to be used. Parallelization, miniaturization, and automation are the main concepts involved in increasing the rate of chemical and biological experimentation. Copyright © 2006 Norbert Stoll et al.

2023, Hörner, Maximilian, Becker, Jan, Bohnert, Rebecca, Baños, Miguel, Jerez‐Longres, Carolina, Mühlhäuser, Vanessa, Härrer, Daniel, Wong, Tin Wang, Meier, Matthias, Weber, Wilfried

Hydrogels with adjustable mechanical properties have been engineered as matrices for mammalian cells and allow the dynamic, mechano-responsive manipulation of cell fate and function. Recent research yields hydrogels, where biological photoreceptors translated optical signals into a reversible and adjustable change in hydrogel mechanics. While their initial application provides important insights into mechanobiology, broader implementation is limited by a small dynamic range of addressable stiffness. Herein, this limitation is overcome by developing a photoreceptor-based hydrogel with reversibly adjustable stiffness from ≈800 Pa to the sol state. The hydrogel is based on star-shaped polyethylene glycol, functionalized with the red/far-red light photoreceptor phytochrome B (PhyB), or phytochrome-interacting factor 6 (PIF6). Upon illumination with red light, PhyB heterodimerizes with PIF6, thus crosslinking the polymers and resulting in gelation. However, upon illumination with far-red light, the proteins dissociate and trigger a complete gel-to-sol transition. The hydrogel's light-responsive mechanical properties are comprehensively characterized and it is applied as a reversible extracellular matrix for the spatiotemporally controlled deposition of mammalian cells within a microfluidic chip. It is anticipated that this technology will open new avenues for the site- and time-specific positioning of cells and will contribute to overcome spatial restrictions.

2016, Chemnitz, Mario, Schmidt, Markus A.

Optical fibers with sub-wavelength cores are promising systems for efficient nonlinear light generation. Here we reveal that the single-mode criterion represents a convenient design tool to optimize the performance of nonlinear fibers circumventing intense numerical calculations. We introduce a quasi-analytic expression for the nonlinear coefficient allowing us to investigate its behavior over a large parameter range. The study is independent of the actual value of the material nonlinearity and shows the fundamental dependencies of the nonlinear coefficient on wavelength, refractive index and core diameter, elucidated by detailed case studies of fused silica and chalcogenide tapers and hybrid fibers.

2018, Chemnitz, Mario, Gaida, Christian, Gebhardt, Martin, Stutzki, Fabian, Kobelke, Jens, Tünnermann, Andreas, Limpert, Jens, Schmidt, Markus A.

Liquid-core fibers offer local external control over pulse dispersion due to their strong thermodynamic response, offering a new degree of freedom in accurate soliton steering for reconfigurable nonlinear light generation. Here, we show how to accurately control soliton dynamics and supercontinuum generation in carbon disulfide/silica fibers by temperature and pressure tuning, monitored via the spectral location and the onset energy of non-solitonic radiation. Simulations and phase-matching calculations based on an extended thermodynamic dispersion model of carbon disulfide confirm the experimental results, which allows us to demonstrate the potential of temperature detuning of liquid-core fibers for octave spanning recompressible supercontinuum generation in the near-infrared.