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- ItemLiquid-Phase Electron Microscopy for Soft Matter Science and Biology(Weinheim : Wiley-VCH Verlag, 2020) Wu, H.; Friedrich, H.; Patterson, J.P.; Sommerdijk, N.A.J.M.; de Jonge, N.Innovations in liquid-phase electron microscopy (LP-EM) have made it possible to perform experiments at the optimized conditions needed to examine soft matter. The main obstacle is conducting experiments in such a way that electron beam radiation can be used to obtain answers for scientific questions without changing the structure and (bio)chemical processes in the sample due to the influence of the radiation. By overcoming these experimental difficulties at least partially, LP-EM has evolved into a new microscopy method with nanometer spatial resolution and sub-second temporal resolution for analysis of soft matter in materials science and biology. Both experimental design and applications of LP-EM for soft matter materials science and biological research are reviewed, and a perspective of possible future directions is given.
- ItemIntegrating Biophysics in Toxicology(Basel : MDPI, 2020) Del Favero, G.; Kraegeloh, A.Integration of biophysical stimulation in test systems is established in diverse branches of biomedical sciences including toxicology. This is largely motivated by the need to create novel experimental setups capable of reproducing more closely in vivo physiological conditions. Indeed, we face the need to increase predictive power and experimental output, albeit reducing the use of animals in toxicity testing. In vivo, mechanical stimulation is essential for cellular homeostasis. In vitro, diverse strategies can be used to model this crucial component. The compliance of the extracellular matrix can be tuned by modifying the stiffness or through the deformation of substrates hosting the cells via static or dynamic strain. Moreover, cells can be cultivated under shear stress deriving from the movement of the extracellular fluids. In turn, introduction of physical cues in the cell culture environment modulates differentiation, functional properties, and metabolic competence, thus influencing cellular capability to cope with toxic insults. This review summarizes the state of the art of integration of biophysical stimuli in model systems for toxicity testing, discusses future challenges, and provides perspectives for the further advancement of in vitro cytotoxicity studies.
- ItemInferring causation from time series in Earth system sciences([London] : Nature Publishing Group UK, 2019) Runge, Jakob; Bathiany, Sebastian; Bollt, Erik; Camps-Valls, Gustau; Coumou, Dim; Deyle, Ethan; Glymour, Clark; Kretschmer, Marlene; Mahecha, Miguel D.; Muñoz-Marí, Jordi; van Nes, Egbert H.; Peters, Jonas; Quax, Rick; Reichstein, Markus; Scheffer, Marten; Schölkopf, Bernhard; Spirtes, Peter; Sugihara, George; Sun, Jie; Zhang, Kun; Zscheischler, JakobThe heart of the scientific enterprise is a rational effort to understand the causes behind the phenomena we observe. In large-scale complex dynamical systems such as the Earth system, real experiments are rarely feasible. However, a rapidly increasing amount of observational and simulated data opens up the use of novel data-driven causal methods beyond the commonly adopted correlation techniques. Here, we give an overview of causal inference frameworks and identify promising generic application cases common in Earth system sciences and beyond. We discuss challenges and initiate the benchmark platform causeme.net to close the gap between method users and developers. © 2019, The Author(s).
- ItemA guide to super-resolution fluorescence microscopy(New York, NY : Rockefeller Univ. Press, 2010) Schermelleh, L.; Heintzmann, R.; Leonhardt, H.For centuries, cell biology has been based on light microscopy and at the same time been limited by its optical resolution. However, several new technologies have been developed recently that bypass this limit. These new super-resolution technologies are either based on tailored illumination, nonlinear fluorophore responses, or the precise localization of single molecules. Overall, these new approaches have created unprecedented new possibilities to investigate the structure and function of cells. © 2010 Schermelleh et al.
- ItemInterglacials of the last 800,000 years(Hoboken, NJ : Blackwell Publishing Ltd, 2016) Berger, B.; Crucifix, M.; Hodell, D.A.; Mangili, C.; McManus, J.F.; Otto-Bliesner, B.; Pol, K.; Raynaud, D.; Skinner, L.C.; Tzedakis, P.C.; Wolff, E.W.; Yin, Q.Z.; Abe-Ouchi, A.; Barbante, C.; Brovkin, V.; Cacho, I.; Capron, E.; Ferretti, P.; Ganopolski, A.; Grimalt, J.O.; Hönisch, B.; Kawamura, K.A.; Landais, A.; Margari, V.; Martrat, B.; Masson-Delmotte, V.; Mokeddem, Z.; Parrenin, F.; Prokopenko, A.A.; Rashid, H.; Schulz, M.; Vazquez Riveiros, N.
- ItemCure kinetics of epoxy nanocomposites affected by MWCNTs functionalization: A review(Boynton Beach, Fla. : Hindawi, 2013) Saeb, M.R.; Bakhshandeh, E.; Khonakdar, H.A.; Mäder, E.; Scheffler, C.; Heinrich, G.The current paper provides an overview to emphasize the role of functionalization of multiwalled carbon nanotubes (MWCNTs) in manipulating cure kinetics of epoxy nanocomposites, which itself determines ultimate properties of the resulting compound. In this regard, the most commonly used functionalization schemes, that is, carboxylation and amidation, are thoroughly surveyed to highlight the role of functionalized nanotubes in controlling the rate of autocatalytic and vitrification kinetics. The current literature elucidates that the mechanism of curing in epoxy/MWCNTs nanocomposites remains almost unaffected by the functionalization of carbon nanotubes. On the other hand, early stage facilitation of autocatalytic reactions in the presence of MWCNTs bearing amine groups has been addressed by several researchers. When carboxylated nanotubes were used to modify MWCNTs, the rate of such reactions diminished as a consequence of heterogeneous dispersion within the epoxy matrix. At later stages of curing, however, the prolonged vitrification was seen to be dominant. Thus, the type of functional groups covalently located on the surface of MWCNTs directly affects the degree of polymer-nanotube interaction followed by enhancement of curing reaction. Our survey demonstrated that most widespread efforts ever made to represent multifarious surface-treated MWCNTs have not been directed towards preparation of epoxy nanocomposites, but they could result in property synergism.
- ItemArticulating the effect of food systems innovation on the Sustainable Development Goals(Amsterdam : Elsevier, 2021) Herrero, Mario; Thornton, Philip K.; Mason-D'Croz, Daniel; Palmer, Jeda; Bodirsky, Benjamin L.; Pradhan, Prajal; Barrett, Christopher B.; Benton, Tim G.; Hall, Andrew; Pikaar, Ilje; Bogard, Jessica R.; Bonnett, Graham D.; Bryan, Brett A.; Campbell, Bruce M.; Christensen, Svend; Clark, Michael; Fanzo, Jessica; Godde, Cecile M.; Jarvis, Andy; Loboguerrero, Ana Maria; Mathys, Alexander; McIntyre, C. Lynne; Naylor, Rosamond L.; Nelson, Rebecca; Obersteiner, Michael; Parodi, Alejandro; Popp, Alexander; Ricketts, Katie; Smith, Pete; Valin, Hugo; Vermeulen, Sonja J.; Vervoort, Joost; van Wijk, Mark; van Zanten, Hannah HE; West, Paul C.; Wood, Stephen A.; Rockström, JohanFood system innovations will be instrumental to achieving multiple Sustainable Development Goals (SDGs). However, major innovation breakthroughs can trigger profound and disruptive changes, leading to simultaneous and interlinked reconfigurations of multiple parts of the global food system. The emergence of new technologies or social solutions, therefore, have very different impact profiles, with favourable consequences for some SDGs and unintended adverse side-effects for others. Stand-alone innovations seldom achieve positive outcomes over multiple sustainability dimensions. Instead, they should be embedded as part of systemic changes that facilitate the implementation of the SDGs. Emerging trade-offs need to be intentionally addressed to achieve true sustainability, particularly those involving social aspects like inequality in its many forms, social justice, and strong institutions, which remain challenging. Trade-offs with undesirable consequences are manageable through the development of well planned transition pathways, careful monitoring of key indicators, and through the implementation of transparent science targets at the local level.
- ItemTowards dynamical network biomarkers in neuromodulation of episodic migraine(Berlin : De Gruyter, 2013) Dahlem, M.A.; Rode, S.; May, A.; Fujiwara, N.; Hirata, Y.; Aihara, K.; Kurths, J.Computational methods have complemented experimental and clinical neurosciences and led to improvements in our understanding of the nervous systems in health and disease. In parallel, neuromodulation in form of electric and magnetic stimulation is gaining increasing acceptance in chronic and intractable diseases. In this paper, we firstly explore the relevant state of the art in fusion of both developments towards translational computational neuroscience. Then, we propose a strategy to employ the new theoretical concept of dynamical network biomarkers (DNB) in episodic manifestations of chronic disorders. In particular, as a first example, we introduce the use of computational models in migraine and illustrate on the basis of this example the potential of DNB as early-warning signals for neuromodulation in episodic migraine.
- ItemУпровадження принципів відкритого доступу в Україні: сучасний стан і перспективи розвитку(Kyïv : Kyïvsʹkyj nacionalʹnyj universytet kulʹtury i mystectv, 2023-04-24) Kaliuzhna, NataliiaThe purpose of the article is to conduct a comprehensive, objective and critical analysis of the results of research on open access in Ukraine to assess the current state of the topic and identify the aspects which require deeper study in order to develop an effective mechanism for implementing the principles of open access in practice. Research methods. The method of narrative literature review with a defined search strategy and criteria for selecting publications in four databases, such as Dimensions, Scopus, Web of Science and the depository of electronic copies “Scientific Periodicals of Ukraine” was used. The inclusion criteria were articles published by authors affiliated with Ukrainian institutions. The scientific novelty lies in the fact that the literature analysis helped to expand and deepen knowledge about the thematic areas of open access research in Ukraine; to identify previously unknown links and contradictions between studies; and to identify areas that require further studies, which include, in particular, the analysis of factors and barriers that facilitate or prevent Ukrainian authors from disseminating their works in open access, the dynamics of growth and peculiarities of the distribution of the share of open access publications by year and field of study. Conclusions. Open access is one of the main components of Open Science. It serves as a tool for accelerating knowledge sharing, developing science, helping to eliminate inequality, and helping to solve several global problems. The research of Ukrainian scientists focuses on four primary areas of open access research: the development of open access policies at the level of institutions and the state, the introduction of institutional repositories, the launch of open access journals, and the regulation of copyright in open scientific communication.
- ItemOpen Research Knowledge Graph(Goettingen: Cuvillier Verlag, 2024-05-07) Auer, Sören; Ilangovan, Vinodh; Stocker, Markus; Tiwari, Sanju; Vogt, Lars; Bernard-Verdier, Maud; D'Souza, Jennifer; Fadel , Kamel; Farfar, Kheir Eddine; Göpfert , Jan; Haris , Muhammad; Heger, Tina; Hussein, Hassan; Jaradeh, Yaser; Jeschke, Jonathan M.; Jiomekong , Azanzi; Kabongo, Salomon; Karras, Oliver; Kuckertz, Patrick; Kullamann, Felix; Martin, Emily A.; Oelen, Allard; Perez-Alvarez, Ricardo; Prinz, Manuel; Snyder, Lauren D.; Stolten, Detlef; Weinand, Jann M.As we mark the fifth anniversary of the alpha release of the Open Research Knowledge Graph (ORKG), it is both timely and exhilarating to celebrate the significant strides made in this pioneering project. We designed this book as a tribute to the evolution and achievements of the ORKG and as a practical guide encapsulating its essence in a form that resonates with both the general reader and the specialist. The ORKG has opened a new era in the way scholarly knowledge is curated, managed, and disseminated. By transforming vast arrays of unstructured narrative text into structured, machine-processable knowledge, the ORKG has emerged as an essential service with sophisticated functionalities. Over the past five years, our team has developed the ORKG into a vibrant platform that enhances the accessibility and visibility of scientific research. This book serves as a non-technical guide and a comprehensive reference for new and existing users that outlines the ORKG’s approach, technologies, and its role in revolutionizing scholarly communication. By elucidating how the ORKG facilitates the collection, enhancement, and sharing of knowledge, we invite readers to appreciate the value and potential of this groundbreaking digital tool presented in a tangible form. Looking ahead, we are thrilled to announce the upcoming unveiling of promising new features and tools at the fifth-year celebration of the ORKG’s alpha release. These innovations are set to redefine the boundaries of machine assistance enabled by research knowledge graphs. Among these enhancements, you can expect more intuitive interfaces that simplify the user experience, and enhanced machine learning models that improve the automation and accuracy of data curation. We also included a glossary tailored to clarifying key terms and concepts associated with the ORKG to ensure that all readers, regardless of their technical background, can fully engage with and understand the content presented. This book transcends the boundaries of a typical technical report. We crafted this as an inspiration for future applications, a testament to the ongoing evolution in scholarly communication that invites further collaboration and innovation. Let this book serve as both your guide and invitation to explore the ORKG as it continues to grow and shape the landscape of scientific inquiry and communication.