Filters

20221

More filters

20231
Reset filters

Settings

Subject: unactived alkenes ×

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Difluoroalkylative carbonylation of alkenes to access carbonyl difluoro-containing heterocycles: convenient synthesis of gemigliptin
    (Berlin ; Heidelberg : Springer, 2022) Bao, Zhi-Peng; Zhang, Youcan; Wang, Le-Cheng; Wu, Xiao-Feng
    Fluorinated heterocycles play a vital role in pharmaceutical and agrochemical industries. Hence, rapid and efficient construction of fluorinated heterocycles remains highly demanded. Herein, a difluoroalkylative carbonylative cyclization of unactivated alkenes and ethylene gas enabled by palladium catalysis has been developed for the first time toward the synthesis of α-carbonyl difluoro-modified glutarimides. This procedure can also be applied to the synthesis of GeMigliptin which is a medicine approved for the treatment of type 2 diabetes mellitus. [Figure not available: see fulltext.]