Pyrimidinone: Versatile Trojan horse in DNA photodamage?
dc.bibliographicCitation.firstPage | 1598 | |
dc.bibliographicCitation.issue | 9 | |
dc.bibliographicCitation.journalTitle | Photochemical & photobiological sciences | eng |
dc.bibliographicCitation.lastPage | 1606 | |
dc.bibliographicCitation.volume | 14 | |
dc.contributor.author | Micheel, Mathias | |
dc.contributor.author | Torres Ziegenbein, Christian | |
dc.contributor.author | Gilch, Peter | |
dc.contributor.author | Ryseck, Gerald | |
dc.date.accessioned | 2022-08-17T06:28:44Z | |
dc.date.available | 2022-08-17T06:28:44Z | |
dc.date.issued | 2015 | |
dc.description.abstract | (6-4) Photolesions between adjacent pyrimidine DNA bases are prone to secondary photochemistry. It has been shown that singlet excited (6-4) moieties form Dewar valence isomers as well as triplet excitations. We here report on the triplet state of a minimal model for the (6-4) photolesion, 1-methyl-2(1H)-pyrimidinone. Emphasis is laid on its ability to abstract hydrogen atoms from alcohols and carbohydrates. Steady-state and time-resolved experiments consistently yield bimolecular rate constants of ∼104 M−1 s−1 for the hydrogen abstraction. The process also occurs intramolecularly as experiments on zebularine (1-(β-D-ribofuranosyl)-2(1H)-pyrimidinone) show. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/10057 | |
dc.identifier.uri | http://dx.doi.org/10.34657/9095 | |
dc.language.iso | eng | eng |
dc.publisher | Heidelberg : Springer | |
dc.relation.doi | https://doi.org/10.1039/c5pp00114e | |
dc.relation.essn | 1474-9092 | |
dc.rights.license | CC BY 3.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | |
dc.subject.ddc | 620 | |
dc.subject.other | cytidine | eng |
dc.subject.other | DNA | eng |
dc.subject.other | hydrogen | eng |
dc.subject.other | methanol | eng |
dc.subject.other | pyrimidin-2-one beta-ribofuranoside | eng |
dc.title | Pyrimidinone: Versatile Trojan horse in DNA photodamage? | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | IPHT | ger |
wgl.subject | Chemie | ger |
wgl.subject | Biowissenschaften/Biologie | ger |
wgl.type | Zeitschriftenartikel | ger |
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