Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents
dc.bibliographicCitation.firstPage | 4786 | |
dc.bibliographicCitation.issue | 12 | |
dc.bibliographicCitation.journalTitle | Bioactive materials | eng |
dc.bibliographicCitation.lastPage | 4800 | |
dc.bibliographicCitation.volume | 6 | |
dc.contributor.author | Ma, Qing | |
dc.contributor.author | Shi, Xiuying | |
dc.contributor.author | Tan, Xing | |
dc.contributor.author | Wang, Rui | |
dc.contributor.author | Xiong, Kaiqin | |
dc.contributor.author | Maitz, Manfred F. | |
dc.contributor.author | Cui, Yuanyuan | |
dc.contributor.author | Hu, Zhangmei | |
dc.contributor.author | Tu, Qiufen | |
dc.contributor.author | Huang, Nan | |
dc.contributor.author | Shen, Li | |
dc.contributor.author | Yang, Zhilu | |
dc.date.accessioned | 2023-04-20T07:36:00Z | |
dc.date.available | 2023-04-20T07:36:00Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Mimicking the nitric oxide (NO)-release and glycocalyx functions of native vascular endothelium on cardiovascular stent surfaces has been demonstrated to reduce in-stent restenosis (ISR) effectively. However, the practical performance of such an endothelium-mimicking surfaces is strictly limited by the durability of both NO release and bioactivity of the glycocalyx component. Herein, we present a mussel-inspired amine-bearing adhesive coating able to firmly tether the NO-generating species (e.g., Cu-DOTA coordination complex) and glycocalyx-like component (e.g., heparin) to create a durable endothelium-mimicking surface. The stent surface was firstly coated with polydopamine (pDA), followed by a surface chemical cross-link with polyamine (pAM) to form a durable pAMDA coating. Using a stepwise grafting strategy, Cu-DOTA and heparin were covalently grafted on the pAMDA-coated stent based on carbodiimide chemistry. Owing to both the high chemical stability of the pAMDA coating and covalent immobilization manner of the molecules, this proposed strategy could provide 62.4% bioactivity retention ratio of heparin, meanwhile persistently generate NO at physiological level from 5.9 ± 0.3 to 4.8 ± 0.4 × 10−10 mol cm−2 min−1 in 1 month. As a result, the functionalized vascular stent showed long-term endothelium-mimicking physiological effects on inhibition of thrombosis, inflammation, and intimal hyperplasia, enhanced re-endothelialization, and hence efficiently reduced ISR. | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/12052 | |
dc.identifier.uri | http://dx.doi.org/10.34657/11085 | |
dc.language.iso | eng | |
dc.publisher | [Bejing] : KeAi Publishing | |
dc.relation.doi | https://doi.org/10.1016/j.bioactmat.2021.05.009 | |
dc.relation.essn | 2452-199X | |
dc.rights.license | CC BY-NC-ND 4.0 Unported | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject.ddc | 570 | |
dc.subject.ddc | 610 | |
dc.subject.ddc | 630 | |
dc.subject.other | Cardiovascular stents | eng |
dc.subject.other | Endothelium mimicking | eng |
dc.subject.other | Glycocalyx component | eng |
dc.subject.other | Nitric oxide | eng |
dc.subject.other | Surface bioengineering | eng |
dc.title | Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | |
wgl.contributor | IPF | |
wgl.subject | Biowissenschaften/Biologie | ger |
wgl.subject | Medizin, Gesundheit | ger |
wgl.type | Zeitschriftenartikel | ger |
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