Combining carbon nanotubes and chitosan for the vectorization of methotrexate to lung cancer cells

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dc.bibliographicCitation.firstPage2889eng
dc.bibliographicCitation.issue18eng
dc.bibliographicCitation.journalTitleMaterialseng
dc.bibliographicCitation.lastPage711eng
dc.bibliographicCitation.volume12eng
dc.contributor.authorCirillo, G.
dc.contributor.authorVittorio, O.
dc.contributor.authorKunhardt, D.
dc.contributor.authorValli, E.
dc.contributor.authorVoli, F.
dc.contributor.authorFarfalla, A.
dc.contributor.authorCurcio, M.
dc.contributor.authorSpizzirri, U.G.
dc.contributor.authorHampel, S.
dc.date.accessioned2020-07-18T06:12:38Z
dc.date.available2020-07-18T06:12:38Z
dc.date.issued2019
dc.description.abstractA hybrid system composed of multi-walled carbon nanotubes coated with chitosan was proposed as a pH-responsive carrier for the vectorization of methotrexate to lung cancer. The effective coating of the carbon nanostructure by chitosan, quantified (20% by weight) by thermogravimetric analysis, was assessed by combined scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy (N1s signal), respectively. Furthermore, Raman spectroscopy was used to characterize the interaction between polysaccharide and carbon counterparts. Methotrexate was physically loaded onto the nanohybrid and the release profiles showed a pH-responsive behavior with higher and faster release in acidic (pH 5.0) vs. neutral (pH 7.4) environments. Empty nanoparticles were found to be highly biocompatible in either healthy (MRC-5) or cancerous (H1299) cells, with the nanocarrier being effective in reducing the drug toxicity on MRC-5 while enhancing the anticancer activity on H1299.eng
dc.description.fondsLeibniz_Fonds
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://doi.org/10.34657/3612
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/4983
dc.language.isoengeng
dc.publisherBasel : MDPI AGeng
dc.relation.doihttps://doi.org/10.3390/ma12182889
dc.relation.issn1996-1944
dc.rights.licenseCC BY 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subject.ddc620eng
dc.subject.otherLung cancereng
dc.subject.otherMethotrexateeng
dc.subject.otherMulti-walled carbon nanotubeseng
dc.subject.otherNanohybridseng
dc.subject.otherPH responsivityeng
dc.subject.otherBiocompatibilityeng
dc.subject.otherBiological organseng
dc.subject.otherChitosaneng
dc.subject.otherControlled drug deliveryeng
dc.subject.otherDiseaseseng
dc.subject.otherHigh resolution transmission electron microscopyeng
dc.subject.otherHybrid systemseng
dc.subject.otherNanotubeseng
dc.subject.otherScanning electron microscopyeng
dc.subject.otherTargeted drug deliveryeng
dc.subject.otherThermogravimetric analysiseng
dc.subject.otherX ray photoelectron spectroscopyeng
dc.subject.otherAnticancer activitieseng
dc.subject.otherCarbon Nanostructureseng
dc.subject.otherLung Cancereng
dc.subject.otherLung cancer cellseng
dc.subject.otherMethotrexateeng
dc.subject.otherNanohybridseng
dc.subject.otherResponsivityeng
dc.subject.otherScanning and transmission electron microscopyeng
dc.subject.otherMultiwalled carbon nanotubes (MWCN)eng
dc.titleCombining carbon nanotubes and chitosan for the vectorization of methotrexate to lung cancer cellseng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorIFWDeng
wgl.subjectIngenieurwissenschafteneng
wgl.typeZeitschriftenartikeleng
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