Polarization-resolved second-harmonic generation imaging through a multimode fiber

dc.bibliographicCitation.firstPage1065eng
dc.bibliographicCitation.issue8eng
dc.bibliographicCitation.lastPage1074eng
dc.bibliographicCitation.volume8eng
dc.contributor.authorCifuentes, Angel
dc.contributor.authorPikálek, Tomáš
dc.contributor.authorOndráčková, Petra
dc.contributor.authorAmezcua-Correa, Rodrigo
dc.contributor.authorAntonio-Lopez, José Enrique
dc.contributor.authorČižmár, Tomáš
dc.contributor.authorTrägårdh, Johanna
dc.date.accessioned2022-03-31T09:31:40Z
dc.date.available2022-03-31T09:31:40Z
dc.date.issued2021
dc.description.abstractMultimode fiber-based endoscopes have recently emerged as a tool for minimally invasive endoscopy in tissue, at depths well beyond the reach of multiphoton imaging. Here, we demonstrate label-free second-harmonic generation (SHG) microscopy through such a fiber endoscope. We simultaneously fully control the excitation polarization state and the spatial distribution of the light at the fiber tip, and we use this to implement polarization-resolved SHG imaging, which allows imaging and identification of structural proteins such as collagen and myosin. We image mouse tail tendon and heart tissue, employing the endoscope at depths up to 1 mm, demonstrating that we can differentiate these structural proteins. This method has the potential for enabling instant and in situ diagnosis of tumors and fibrotic conditions in sensitive tissue with minimal damage.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/8485
dc.identifier.urihttps://doi.org/10.34657/7523
dc.language.isoengeng
dc.publisherWashington, DC : OSAeng
dc.relation.doihttps://doi.org/10.1364/OPTICA.430295
dc.relation.essn2334-2536
dc.relation.ispartofseriesOptica 8 (2021), Nr. 8eng
dc.rights.licenseOSA Open Access Publishing Agreementeng
dc.rights.urihttps://www.osapublishing.org/library/license_v1.cfmeng
dc.subjectEndoscopyeng
dc.subjectExcited stateseng
dc.subjectFiberseng
dc.subjectMultimode fiberseng
dc.subjectNonlinear opticseng
dc.subjectPolarizationeng
dc.subjectProteinseng
dc.subjectTissueeng
dc.subjectHeart tissueseng
dc.subjectMinimal damageeng
dc.subjectMinimally invasiveeng
dc.subjectMultiphoton imagingeng
dc.subjectPolarization stateeng
dc.subjectSecond harmonic generation microscopies (SHG)eng
dc.subjectSecond harmonicseng
dc.subjectStructural proteinseng
dc.subjectHarmonic generationeng
dc.subject.ddc530eng
dc.subject.ddc620eng
dc.titlePolarization-resolved second-harmonic generation imaging through a multimode fibereng
dc.typearticleeng
dc.typeTexteng
dcterms.bibliographicCitation.journalTitleOpticaeng
tib.accessRightsopenAccesseng
wgl.contributorIPHTeng
wgl.subjectPhysikeng
wgl.typeZeitschriftenartikeleng
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