Wet-Spinning of Biocompatible Core–Shell Polyelectrolyte Complex Fibers for Tissue Engineering
dc.bibliographicCitation.firstPage | 2000849 | eng |
dc.bibliographicCitation.issue | 23 | eng |
dc.bibliographicCitation.journalTitle | Advanced materials interfaces | eng |
dc.bibliographicCitation.lastPage | 158 | eng |
dc.bibliographicCitation.volume | 7 | eng |
dc.contributor.author | Cui, Qing | |
dc.contributor.author | Bell, Daniel Josef | |
dc.contributor.author | Rauer, Sebastian Bernhard | |
dc.contributor.author | Wessling, Matthias | |
dc.date.accessioned | 2021-07-30T05:05:05Z | |
dc.date.available | 2021-07-30T05:05:05Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Polyelectrolyte complex fibers (PEC fibers) have great potential with regard to biomedical applications as they can be fabricated from biocompatible and water-soluble polyelectrolytes under mild process conditions. The present publication describes a novel method for the continuous fabrication of PEC fibers in a water-based wet-spinning process by interfacial complexation within a core–shell spinneret. This process combines the robustness and flexibility of nonsolvent-induced phase separation (NIPS) spinning processes conventionally used in the membrane industry with the complexation between oppositely charged polyelectrolytes. The produced fibers demonstrate a core–shell structure with a low-density core and a highly porous polyelectrolyte complex shell of ≈800 μm diameter. In the case of chitosan and polystyrene sulfonate (PSS), mechanical fiber properties could be enhanced by doping the PSS with poly(ethylene oxide) (PEO). The resulting CHI/PSS-PEO fibers present a Young modulus of 3.78 GPa and a tensile strength of 165 MPa, which is an excellent combination of elongation at break and break stress compared to literature. The suitability of the CHI/PSS-PEO fibers as a scaffold for cell culture applications is verified by a four-day cultivation of human HeLa cells on PEO-reinforced fibers with a subsequent analysis of cell viability by fluorescence-based live/dead assay. © 2020 The Authors. Published by Wiley-VCH GmbH | eng |
dc.description.version | publishedVersion | eng |
dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/6425 | |
dc.identifier.uri | https://doi.org/10.34657/5472 | |
dc.language.iso | eng | eng |
dc.publisher | Weinheim : Wiley-VCH | eng |
dc.relation.doi | https://doi.org/10.1002/admi.202000849 | |
dc.relation.essn | 2196-7350 | |
dc.rights.license | CC BY 4.0 Unported | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject.ddc | 540 | eng |
dc.subject.ddc | 600 | eng |
dc.subject.other | cell culture | eng |
dc.subject.other | core–shell fibers | eng |
dc.subject.other | interfacial polyelectrolyte complex fibers | eng |
dc.subject.other | wet spinning | eng |
dc.title | Wet-Spinning of Biocompatible Core–Shell Polyelectrolyte Complex Fibers for Tissue Engineering | eng |
dc.type | Article | eng |
dc.type | Text | eng |
tib.accessRights | openAccess | eng |
wgl.contributor | DWI | eng |
wgl.subject | Ingenieurwissenschaften | eng |
wgl.type | Zeitschriftenartikel | eng |
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