Enantio- and diastereoselective synthesis of γ-amino alcohols

Verkade, Jorge M. M.; Quaedflieg, Peter J. L. M.; Verzijl, Gerard K. M.; Lefort, Laurent; van Delft, Floris L.; de Vries, Johannes G.; Rutjes, Floris P. J. T.

Enantio- and diastereoselective synthesis of γ-amino alcohols

dc.bibliographicCitation.firstPage	14462	eng
dc.bibliographicCitation.issue	77	eng
dc.bibliographicCitation.journalTitle	Chemical communications : ChemComm	eng
dc.bibliographicCitation.lastPage	14464	eng
dc.bibliographicCitation.volume	51	eng
dc.contributor.author	Verkade, Jorge M. M.
dc.contributor.author	Quaedflieg, Peter J. L. M.
dc.contributor.author	Verzijl, Gerard K. M.
dc.contributor.author	Lefort, Laurent
dc.contributor.author	van Delft, Floris L.
dc.contributor.author	de Vries, Johannes G.
dc.contributor.author	Rutjes, Floris P. J. T.
dc.date.accessioned	2022-06-24T06:03:04Z
dc.date.available	2022-06-24T06:03:04Z
dc.date.issued	2015
dc.description.abstract	The γ-amino alcohol structural motif is often encountered in drugs and natural products. We developed two complementary catalytic diastereoselective methods for the synthesis of N-PMP-protected γ-amino alcohols from the corresponding ketones. The anti-products were obtained through Ir-catalyzed asymmetric transfer hydrogenation, the syn-products via Rh-catalyzed asymmetric hydrogenation.	eng
dc.description.version	publishedVersion	eng
dc.identifier.uri	https://oa.tib.eu/renate/handle/123456789/9257
dc.identifier.uri	https://doi.org/10.34657/8295
dc.language.iso	eng	eng
dc.publisher	Cambridge : Soc.	eng
dc.relation.doi	https://doi.org/10.1039/c5cc04445f
dc.relation.essn	1364-548X
dc.rights.license	CC BY 3.0 Unported	eng
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/	eng
dc.subject.ddc	540	eng
dc.subject.other	aminoalcohol	eng
dc.subject.other	ketone derivative	eng
dc.subject.other	aminoalcohol	eng
dc.subject.other	alcohol production	eng
dc.subject.other	asymmetric catalysis	eng
dc.subject.other	catalyst	eng
dc.subject.other	crystal structure	eng
dc.subject.other	diastereoisomer	eng
dc.subject.other	enantioselectivity	eng
dc.subject.other	hydrogenation	eng
dc.subject.other	quantum yield	eng
dc.subject.other	reaction analysis	eng
dc.subject.other	stereochemistry	eng
dc.subject.other	catalysis	eng
dc.subject.other	chemistry	eng
dc.subject.other	stereoisomerism	eng
dc.subject.other	synthesis	eng
dc.subject.other	Amino Alcohols	eng
dc.subject.other	Catalysis	eng
dc.subject.other	Hydrogenation	eng
dc.subject.other	Stereoisomerism	eng
dc.title	Enantio- and diastereoselective synthesis of γ-amino alcohols	eng
dc.type	Article	eng
dc.type	Text	eng
tib.accessRights	openAccess	eng
wgl.contributor	LIKAT	eng
wgl.subject	Chemie	eng
wgl.type	Zeitschriftenartikel	eng

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