Non-thermal plasma-treated solution demonstrates antitumor activity against pancreatic cancer cells in vitro and in vivo

dc.bibliographicCitation.firstPage8319
dc.bibliographicCitation.issue1
dc.bibliographicCitation.journalTitleScientific reportseng
dc.bibliographicCitation.volume7
dc.contributor.authorLiedtke, Kim Rouven
dc.contributor.authorBekeschus, Sander
dc.contributor.authorKaeding, André
dc.contributor.authorHackbarth, Christine
dc.contributor.authorKuehn, Jens-Peter
dc.contributor.authorHeidecke, Claus-Dieter
dc.contributor.authorvon Bernstorff, Wolfram
dc.contributor.authorvon Woedtke, Thomas
dc.contributor.authorPartecke, Lars Ivo
dc.date.accessioned2023-01-16T09:31:47Z
dc.date.available2023-01-16T09:31:47Z
dc.date.issued2017
dc.description.abstractPancreatic cancer is associated with a high mortality rate. In advanced stage, patients often experience peritoneal carcinomatosis. Using a syngeneic murine pancreatic cancer cell tumor model, the effect of non-thermal plasma (NTP) on peritoneal metastatic lesions was studied. NTP generates reactive species of several kinds which have been proven to be of relevance in cancer. In vitro, exposure to both plasma and plasma-treated solution significantly decreased cell viability and proliferation of 6606PDA cancer cells, whereas mouse fibroblasts were less affected. Repeated intraperitoneal treatment of NTP-conditioned medium decreased tumor growth in vivo as determined by magnetic resonance imaging, leading to reduced tumor mass and improved median survival (61 vs 52 days; p < 0.024). Tumor nodes treated by NTP-conditioned medium demonstrated large areas of apoptosis with strongly inhibited cell proliferation. Contemporaneously, no systemic effects were found. Apoptosis was neither present in the liver nor in the gut. Also, the concentration of different cytokines in splenocytes or blood plasma as well as the distribution of various hematological parameters remained unchanged following treatment with NTP-conditioned medium. These results suggest an anticancer role of NTP-treated solutions with little to no systemic side effects being present, making NTP-treated solutions a potential complementary therapeutic option for advanced tumors.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/10866
dc.identifier.urihttp://dx.doi.org/10.34657/9892
dc.language.isoeng
dc.publisher[London] : Macmillan Publishers Limited
dc.relation.doihttps://doi.org/10.1038/s41598-017-08560-3
dc.relation.essn2045-2322
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subject.ddc500
dc.subject.ddc600
dc.subject.otherAnimalseng
dc.subject.otherAntineoplastic Agentseng
dc.subject.otherApoptosiseng
dc.subject.otherBiomarkerseng
dc.subject.otherCell Line, Tumoreng
dc.subject.otherCell Proliferationeng
dc.subject.otherCell Survivaleng
dc.subject.otherHumanseng
dc.subject.otherMagnetic Resonance Imagingeng
dc.subject.otherMiceeng
dc.subject.otherMice, Transgeniceng
dc.subject.otherOxidation-Reductioneng
dc.subject.otherPancreatic Neoplasmseng
dc.subject.otherPlasma Gaseseng
dc.subject.otherReactive Oxygen Specieseng
dc.titleNon-thermal plasma-treated solution demonstrates antitumor activity against pancreatic cancer cells in vitro and in vivoeng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccess
wgl.contributorINP
wgl.subjectMedizin, Gesundheitger
wgl.typeZeitschriftenartikelger
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