Urban brown rats (Rattus norvegicus) as possible source of multidrug-resistant Enterobacteriaceae and meticillin-resistant Staphylococcus spp., Vienna, Austria, 2016 and 2017

dc.bibliographicCitation.firstPage1900149eng
dc.bibliographicCitation.issue32eng
dc.bibliographicCitation.journalTitleEurosurveillanceeng
dc.bibliographicCitation.volume24eng
dc.contributor.authorDesvars-Larrive, Amélie
dc.contributor.authorRuppitsch, Werner
dc.contributor.authorLepuschitz, Sarah
dc.contributor.authorSzostak, Michael P.
dc.contributor.authorSpergser, Joachim
dc.contributor.authorFeßler, Andrea T.
dc.contributor.authorSchwarz, Stefan
dc.contributor.authorMonecke, Stefan
dc.contributor.authorEhricht, Ralf
dc.contributor.authorWalzer, Chris
dc.contributor.authorLoncaric, Igor
dc.date.accessioned2021-10-19T12:49:32Z
dc.date.available2021-10-19T12:49:32Z
dc.date.issued2019
dc.description.abstractBackground: Brown rats (Rattus norvegicus) are an important wildlife species in cities, where they live in close proximity to humans. However, few studies have investigated their role as reservoir of antimicrobial-resistant bacteria. Aim: We intended to determine whether urban rats at two highly frequented sites in Vienna, Austria, carry extended-spectrum β-lactamase-producing Enterobacteriaceae, fluoroquinolone-resistant Enterobacteriaceae and meticillin-resistant (MR) Staphylococcus spp. (MRS). Methods: We surveyed the presence of antimicrobial resistance in 62 urban brown rats captured in 2016 and 2017 in Vienna, Austria. Intestinal and nasopharyngeal samples were cultured on selective media. We character-ised the isolates and their antimicrobial properties using microbiological and genetic methods including disk diffusion, microarray analysis, sequencing, and detection and characterisation of plasmids. Results: Eight multidrug-resistant Escherichia coli and two extensively drug-resistant New Delhi metallo-β-lactamases-1 (NDM-1)-producing Enterobacter xiangfangensis ST114 (En. cloacae complex) were isolated from nine of 62 rats. Nine Enterobacteriaceae isolates harboured the blaCTX-M gene and one carried a plasmid-encoded ampC gene (blaCMY-2). Forty-four MRS were isolated from 37 rats; they belonged to seven different staphylococcal species: S. fleuret-tii, S. sciuri, S. aureus, S. pseudintermedius, S. epidermidis, S. haemolyticus (all mecA-positive) and mecC-positive S. xylosus. Conclusion: Our findings suggest that brown rats in cities are a potential source of multidrug-resistant bacteria, including carbapenem-resistant En. xiangfangensis ST114. Considering the increasing worldwide urbanisation, rodent control remains an important priority for health in modern cities. © 2019, European Centre for Disease Prevention and Control (ECDC). All rights reserved.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/7050
dc.identifier.urihttps://doi.org/10.34657/6097
dc.language.isoengeng
dc.publisherStockholm : European Centre for Disease Prevention and Controleng
dc.relation.doihttps://doi.org/10.2807/1560-7917.ES.2019.24.32.1900149
dc.relation.essn1560-7917
dc.relation.issn1025-496X
dc.rights.licenseCC BY 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subject.ddc610eng
dc.subject.otherbeta lactamase CTX Meng
dc.subject.othermeticillineng
dc.subject.otherquinoline derived antiinfective agenteng
dc.subject.otherantiinfective agenteng
dc.subject.otheranimal tissueeng
dc.subject.otherantibiotic resistanceeng
dc.subject.otherAustriaeng
dc.subject.otherbacterial geneeng
dc.subject.otherbacterial straineng
dc.subject.otherbacterium isolationeng
dc.subject.otherblaCTX M geneeng
dc.subject.otherdisk diffusioneng
dc.subject.otherDNA microarrayeng
dc.subject.otherEnterobacter cloacaeeng
dc.subject.otherEnterobacter xiangfangensis ST114eng
dc.subject.otherextended spectrum beta lactamase producing Enterobacteriaceaeeng
dc.subject.otherfluoroquinolone resistanceeng
dc.subject.othergene sequenceeng
dc.subject.othergenetic analysiseng
dc.subject.othermecA geneeng
dc.subject.othermecC geneeng
dc.subject.othermethicillin resistant Staphylococcus aureuseng
dc.subject.othermicroarray analysiseng
dc.subject.othermicrobiological examinationeng
dc.subject.othermultidrug resistant Enterobacteriaceaeeng
dc.subject.othermultidrug resistant Escherichia colieng
dc.subject.othernasopharynxeng
dc.subject.otherplasmideng
dc.subject.otherrateng
dc.subject.otherRattus norvegicuseng
dc.subject.otherStaphylococcus aureuseng
dc.subject.otherStaphylococcus epidermidiseng
dc.subject.otherStaphylococcus fleurettiieng
dc.subject.otherStaphylococcus haemolyticuseng
dc.subject.otherStaphylococcus pseudintermediuseng
dc.subject.otherStaphylococcus sciurieng
dc.subject.otherStaphylococcus xylosuseng
dc.subject.otherDNA sequenceeng
dc.subject.otherEnterobacteriaceae infectioneng
dc.subject.othermethicillin resistant Staphylococcus aureuseng
dc.titleUrban brown rats (Rattus norvegicus) as possible source of multidrug-resistant Enterobacteriaceae and meticillin-resistant Staphylococcus spp., Vienna, Austria, 2016 and 2017eng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorIPHTeng
wgl.subjectMedizin, Gesundheiteng
wgl.typeZeitschriftenartikeleng
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