Antimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing Block Copolymers

dc.bibliographicCitation.articleNumber2200665
dc.bibliographicCitation.issue8
dc.bibliographicCitation.volume308
dc.contributor.authorMethling, Rafael
dc.contributor.authorDückmann, Oliver
dc.contributor.authorSimon, Frank
dc.contributor.authorWolf‐Brandstetter, Cornelia
dc.contributor.authorKuckling, Dirk
dc.date.accessioned2023-06-02T15:00:33Z
dc.date.available2023-06-02T15:00:33Z
dc.date.issued2023
dc.description.abstractCoating medical implants with antibacterial polymers may prevent postoperative infections which are a common issue for conventional titanium implants and can even lead to implant failure. Easily applicable diblock copolymers are presented that form polymer brushes via “grafting to” mechanism on titanium and equip the modified material with antibacterial properties. The polymers carry quaternized pyridinium units to combat bacteria and phosphonic acid groups which allow the linear chains to be anchored to metal surfaces in a convenient coating process. The polymers are synthesized via reversible-addition-fragmentation-chain-transfer (RAFT) polymerization and postmodifications and are characterized using NMR spectroscopy and SEC. Low grafting densities are a major drawback of the “grafting to” approach compared to “grafting from”. Thus, the number of phosphonic acid groups in the anchor block are varied to investigate and optimize the surface binding. Modified titanium surfaces are examined regarding their composition, wetting behavior, streaming potential, and coating stability. Evaluation of the antimicrobial properties revealed reduced bacterial adhesion and biofilm formation for certain polymers, albeit the cell biocompatibility against human gingival fibroblasts is also impaired. The presented findings show the potential of easy-to-apply polymer coatings and aid in designing next-generation implant surface modifications.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/12261
dc.identifier.urihttp://dx.doi.org/10.34657/11293
dc.language.isoeng
dc.publisherWeinheim : Wiley-VCH GmbH
dc.relation.doihttps://doi.org/10.1002/mame.202200665
dc.relation.essn1439-2054
dc.relation.ispartofseriesMacromolecular materials and engineering 308 (2023), Nr. 8eng
dc.relation.issn1438-7492
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectantimicrobial polymerseng
dc.subjectantimicrobial surfaceseng
dc.subjectgrafting toeng
dc.subjectpolymer brusheseng
dc.subject.ddc540
dc.titleAntimicrobial Brushes on Titanium via “Grafting to” Using Phosphonic Acid/Pyridinium Containing Block Copolymerseng
dc.typearticle
dc.typeText
dcterms.bibliographicCitation.journalTitleMacromolecular materials and engineering
tib.accessRightsopenAccess
wgl.contributorIPF
wgl.subjectChemieger
wgl.typeZeitschriftenartikelger
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