Dehydroabietylamine-Based Cellulose Nanofibril Films: A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects

dc.bibliographicCitation.firstPage5002eng
dc.bibliographicCitation.issue5eng
dc.bibliographicCitation.lastPage5009eng
dc.bibliographicCitation.volume7eng
dc.contributor.authorHassan, Ghada
dc.contributor.authorForsman, Nina
dc.contributor.authorWan, Xing
dc.contributor.authorKeurulainen, Leena
dc.contributor.authorBimbo, Luis M.
dc.contributor.authorJohansson, Leena-Sisko
dc.contributor.authorSipari, Nina
dc.contributor.authorYli-Kauhaluoma, Jari
dc.contributor.authorZimmermann, Ralf
dc.contributor.authorStehl, Susanne
dc.contributor.authorWerner, Carsten
dc.contributor.authorSaris, Per E.J.
dc.contributor.authorÖsterberg, Monika
dc.contributor.authorMoreira, Vânia M.
dc.date.accessioned2021-09-02T09:28:29Z
dc.date.available2021-09-02T09:28:29Z
dc.date.issued2019
dc.description.abstractThe design of antimicrobial surfaces as integral parts of advanced biomaterials is nowadays a high research priority, as the accumulation of microorganisms on surfaces inflicts substantial costs on the health and industry sectors. At present, there is a growing interest in designing functional materials from polymers abundant in nature, such as cellulose, that combine sustainability with outstanding mechanical properties and economic production. There is also the need to find suitable replacements for antimicrobial silver-based agents due to environmental toxicity and spread of resistance to metal antimicrobials. Herein we report the unprecedented decoration of cellulose nanofibril (CNF) films with dehydroabietylamine 1 (CNF-CMC-1), to give an innovative contact-active surface active against Gram-positive and Gram-negative bacteria including the methicillin-resistant S. aureus MRSA14TK301, with low potential to spread resistance and good biocompatibility, all achieved with low surface coverage. CNF-CMC-1 was particularly effective against S. aureus ATCC12528, causing virtually complete reduction of the total cells from 10 5 colony forming units (CFU)/mL bacterial suspensions, after 24 h of contact. This gentle chemical modification of the surface of CNF fully retained the beneficial properties of the original film, including moisture buffering and strength, relevant in many potential applications. Our originally designed surface represents a new class of ecofriendly biomaterials that optimizes the performance of CNF by adding antimicrobial properties without the need for environmentally toxic silver. © Copyright 2019 American Chemical Society.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/6662
dc.identifier.urihttps://doi.org/10.34657/5709
dc.language.isoengeng
dc.publisherWashington, DC : ACS Publicationseng
dc.relation.doihttps://doi.org/10.1021/acssuschemeng.8b05658
dc.relation.essn2168-0485
dc.relation.ispartofseriesACS Sustainable Chemistry and Engineering 7 (2019), Nr. 5eng
dc.rights.licenseCC BY 4.0 Unportedeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subjectAntimicrobialeng
dc.subjectBiomaterialseng
dc.subjectDehydroabietylamineeng
dc.subjectDrug-resistanteng
dc.subjectNanocelluloseeng
dc.subjectSilvereng
dc.subject.ddc540eng
dc.titleDehydroabietylamine-Based Cellulose Nanofibril Films: A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effectseng
dc.typearticleeng
dc.typeTexteng
dcterms.bibliographicCitation.journalTitleACS Sustainable Chemistry and Engineeringeng
tib.accessRightsopenAccesseng
wgl.contributorIPFeng
wgl.subjectChemieeng
wgl.typeZeitschriftenartikeleng
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