Related carbapenemase-producing Klebsiella isolates detected in both a hospital and associated aquatic environment in Sweden

dc.bibliographicCitation.firstPage2241
dc.bibliographicCitation.issue12
dc.bibliographicCitation.journalTitleEuropean journal of clinical microbiology & infectious diseaseseng
dc.bibliographicCitation.lastPage2251
dc.bibliographicCitation.volume37
dc.contributor.authorKhan, Faisal Ahmad
dc.contributor.authorHellmark, Bengt
dc.contributor.authorEhricht, Ralf
dc.contributor.authorSöderquist, Bo
dc.contributor.authorJass, Jana
dc.date.accessioned2023-01-19T09:43:51Z
dc.date.available2023-01-19T09:43:51Z
dc.date.issued2018-8-31
dc.description.abstractCarbapenem antibiotics are one of the last-resort agents against multidrug-resistant (MDR) bacteria. The occurrence of carbapenemase-producing Enterobacteriaceae (CPE) in wastewater and aquatic environments is an indication of MDR bacteria in the community. This study evaluated CPE in aquatic environments and compared them to the local hospital isolates in Sweden. Phenotypic and genotypic analyses of antibiotic resistance of environmental and clinical CPE were performed. The relatedness of the isolates and possible clonal dissemination was evaluated using phylogenetic and phyloproteomic analysis. Klebsiella oxytoca carrying carbapenemase genes (blaVIM-1, blaIMP-29) were isolated from wastewater and the recipient river, while K. oxytoca (blaVIM-1) and Klebsiella pneumoniae (blaVIM-1, blaOXA-48, blaNDM-1, blaKPC-3) were isolated from patients at the local clinics or hospital. The K. oxytoca classified as sequence type 172 (ST172) isolated from the river was genotypically related to two clinical isolates recovered from patients. The similarity between environmental and clinical isolates suggests the dispersion of blaVIM-1 producing K. oxytoca ST172 from hospital to aquatic environment and the likelihood of its presence in the community. This is the first report of CPE in aquatic environments in Sweden; therefore, surveillance of aquatic and hospital environments for CPE in other urban areas is important to determine the major transfer routes in order to formulate strategies to prevent the spread of MDR bacteria.eng
dc.description.versionpublishedVersioneng
dc.identifier.urihttps://oa.tib.eu/renate/handle/123456789/10940
dc.identifier.urihttp://dx.doi.org/10.34657/9966
dc.language.isoeng
dc.publisherBerlin ; Heidelberg ; New York : Springer
dc.relation.doihttps://doi.org/10.1007/s10096-018-3365-9
dc.relation.essn1435-4373
dc.relation.issn0934-9723
dc.rights.licenseCC BY 4.0 Unported
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subject.ddc610
dc.subject.otherAntimicrobial resistanceeng
dc.subject.otherCarbapenemase-producing Enterobacteriaceaeeng
dc.subject.otherExtended spectrum beta-lactamaseeng
dc.subject.otherKlebsiella oxytocaeng
dc.subject.otherKlebsiella pneumoniaeeng
dc.subject.otherMultidrug resistanceeng
dc.titleRelated carbapenemase-producing Klebsiella isolates detected in both a hospital and associated aquatic environment in Swedeneng
dc.typeArticleeng
dc.typeTexteng
tib.accessRightsopenAccesseng
wgl.contributorIPHT
wgl.subjectMedizin, Gesundheitger
wgl.typeZeitschriftenartikelger
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Related_carbapenemase-producing.pdf
Size:
1.48 MB
Format:
Adobe Portable Document Format
Description:
Collections