Difluoroalkylative carbonylation of alkenes to access carbonyl difluoro-containing heterocycles: convenient synthesis of gemigliptin
| dc.bibliographicCitation.date | 2023 | |
| dc.bibliographicCitation.firstPage | 139 | |
| dc.bibliographicCitation.issue | 1 | |
| dc.bibliographicCitation.journalTitle | Science China Chemistry | eng |
| dc.bibliographicCitation.lastPage | 146 | |
| dc.bibliographicCitation.volume | 66 | |
| dc.contributor.author | Bao, Zhi-Peng | |
| dc.contributor.author | Zhang, Youcan | |
| dc.contributor.author | Wang, Le-Cheng | |
| dc.contributor.author | Wu, Xiao-Feng | |
| dc.date.accessioned | 2023-02-10T09:22:55Z | |
| dc.date.available | 2023-02-10T09:22:55Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Fluorinated heterocycles play a vital role in pharmaceutical and agrochemical industries. Hence, rapid and efficient construction of fluorinated heterocycles remains highly demanded. Herein, a difluoroalkylative carbonylative cyclization of unactivated alkenes and ethylene gas enabled by palladium catalysis has been developed for the first time toward the synthesis of α-carbonyl difluoro-modified glutarimides. This procedure can also be applied to the synthesis of GeMigliptin which is a medicine approved for the treatment of type 2 diabetes mellitus. [Figure not available: see fulltext.] | eng |
| dc.description.version | publishedVersion | eng |
| dc.identifier.uri | https://oa.tib.eu/renate/handle/123456789/11406 | |
| dc.identifier.uri | http://dx.doi.org/10.34657/10440 | |
| dc.language.iso | eng | |
| dc.publisher | Berlin ; Heidelberg : Springer | |
| dc.relation.doi | https://doi.org/10.1007/s11426-022-1439-1 | |
| dc.relation.essn | 1869-1870 | |
| dc.relation.issn | 1674-7291 | |
| dc.rights.license | CC BY 4.0 Unported | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
| dc.subject.ddc | 540 | |
| dc.subject.other | carbonylative | eng |
| dc.subject.other | difluoroalkylative | eng |
| dc.subject.other | ethylene gas | eng |
| dc.subject.other | heterocycles | eng |
| dc.subject.other | unactived alkenes | eng |
| dc.title | Difluoroalkylative carbonylation of alkenes to access carbonyl difluoro-containing heterocycles: convenient synthesis of gemigliptin | eng |
| dc.type | Article | eng |
| dc.type | Text | eng |
| tib.accessRights | openAccess | |
| wgl.contributor | LIKAT | |
| wgl.subject | Chemie | ger |
| wgl.type | Zeitschriftenartikel | ger |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- s11426-022-1439-1.pdf
- Size:
- 1.59 MB
- Format:
- Adobe Portable Document Format
- Description: